Egyptian Journal of Bronchology· 2026Q2
Association between mean airway pressure and 90-day mortality in ventilator-associated pneumonia
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- Q2SCImago
- 2026year
Short summary
Higher mean airway pressure (Pmean) during mechanical ventilation is associated with increased 90-day mortality in patients with ventilator-associated pneumonia (VAP).
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Key points
- Higher average mean airway pressure (Pmean) was observed in VAP patients who died within 90 days (10.80 cmH₂O) compared to survivors (9.89 cmH₂O).
- The area under the ROC curve for average Pmean as a predictor of 90-day mortality was 0.591.
- Patients with Pmean above the median (10.06 cmH₂O) showed worse 90-day survival.
- 23.8% of the 2,911 VAP patients analyzed died within 90 days.
AI-generated from the title and abstract; the full text is not read.
Abstract
Abstract Objective We performed a retrospective cohort analysis to assess the association between mean airway pressure (Pmean) during mechanical ventilation and 90-day mortality in patients with ventilator-associated pneumonia (VAP). Results Of the 2,911 VAP cases retrieved from MIMIC-IV, 693 patients (23.8%) had died within 90 days. Non-survivors showed a significantly higher average Pmean than survivors (median [IQR]:10.80 [8.85, 13.89] vs. 9.89 [8.28, 12.04]; P < 0.001). The area under the receiver operating characteristic (ROC) curve (AUC) for average Pmean was 0.591. When patients were divided by median Pmean (10.06 cmH₂O), those with higher values had worse 90-day survival (log-rank P < 0.001). Conclusions Higher average Pmean was associated with increased 90-day mortality in VAP. These univariable results suggest an association, but validation with multivariable and prospective studies is needed.
The authors' abstract, as published at the source. Egyptian Journal of Bronchology, 2026 · DOI ↗
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Field: Critical Care and Intensive Care Medicine
Critical Care and Intensive Care MedicineMedicine