Key papers in Critical Care and Intensive Care Medicine
Pofolia’s corpus holds 72 papers from the Critical Care and Intensive Care Medicine subfield (2012–2023). The list below starts with the most cited.
Most cited
Ranked by citation count. Because citations accumulate over time, this list naturally leans towards work published a few years ago; for where the field is now, see “recently added”.
Intravenous Fluids and Acute Kidney Injury
Blood Purification · 2017 · Q2 · FWCI 353.84 · 6,842 citations · Open access
Excessive or insufficient intravenous fluid administration can lead to acute kidney injury (AKI), with venous congestion being particularly damaging to the kidney.
Multistate Point-Prevalence Survey of Health Care–Associated Infections
New England Journal of Medicine · 2014 · Q1 · SJR 18.00 · FWCI 185.37 · 3,973 citations · Open access
A survey of 11,282 patients across 10 states found that 4.0% had health care-associated infections (HAIs), totaling an estimated 721,800 infections in U.S. acute care hospitals in 2011.
Management of Adults With Hospital-acquired and Ventilator-associated Pneumonia: 2016 Clinical Practice Guidelines by the Infectious Diseases Society of America and the American Thoracic Society
Clinical Infectious Diseases · 2016 · Q1 · SJR 2.00 · FWCI 218.65 · 3,949 citations · Open access
These 2016 clinical practice guidelines offer recommendations for healthcare professionals on the diagnosis and treatment of hospital-acquired and ventilator-associated pneumonia in adults.
Clinical Practice Guidelines for the Prevention and Management of Pain, Agitation/Sedation, Delirium, Immobility, and Sleep Disruption in Adult Patients in the ICU
Critical Care Medicine · 2018 · Q1 · SJR 1.00 · FWCI 199.14 · 3,906 citations
Updated clinical practice guidelines for ICU patients now include recommendations for immobility and sleep disruption, alongside pain, agitation, and delirium.
Clinical Practice Guidelines for the Management of Pain, Agitation, and Delirium in Adult Patients in the Intensive Care Unit
Critical Care Medicine · 2012 · Q1 · SJR 1.00 · FWCI 122.07 · 3,812 citations
New clinical practice guidelines offer an evidence-based roadmap for managing pain, agitation, and delirium in critically ill adult patients. Developed over six years by a multidisciplinary task force, these guidelines utilize the GRADE methodology to rank evidence quality and recommendation strength.
Long-Term Cognitive Impairment after Critical Illness
New England Journal of Medicine · 2013 · Q1 · SJR 18.00 · FWCI 76.18 · 2,833 citations · Open access
A significant majority of critical illness survivors (74%) experience in-hospital delirium, leading to substantial long-term cognitive impairment, with 40% showing deficits comparable to moderate traumatic brain injury at 3 months post-discharge.
STARD 2015 guidelines for reporting diagnostic accuracy studies: explanation and elaboration
BMJ Open · 2016 · Q1 · FWCI 67.97 · 2,508 citations · Open access
The STARD 2015 statement provides an updated, elaborated explanation of 30 essential items for reporting diagnostic accuracy studies, aiming to improve transparency and trustworthiness of findings.
Transfusion of Plasma, Platelets, and Red Blood Cells in a 1:1:1 vs a 1:1:2 Ratio and Mortality in Patients With Severe Trauma
JAMA · 2015 · Q1 · SJR 5.00 · FWCI 140.35 · 2,495 citations
A large trial found that transfusing severely injured trauma patients with plasma, platelets, and red blood cells in a 1:1:1 ratio did not significantly reduce overall 24-hour or 30-day mortality compared to a 1:1:2 ratio.
Health Care–Associated Infections
JAMA Internal Medicine · 2013 · Q1 · SJR 4.00 · FWCI 54.61 · 1,840 citations
Central line-associated bloodstream infections are the most costly per case ($45,814), while surgical site infections contribute the most to the total annual cost of $9.8 billion for five major health care-associated infections.
Hydroxyethyl Starch 130/0.42 versus Ringer's Acetate in Severe Sepsis
New England Journal of Medicine · 2012 · Q1 · SJR 18.00 · FWCI 116.22 · 1,829 citations
In severe sepsis patients, fluid resuscitation with Hydroxyethyl Starch (HES) 130/0.42 led to a higher risk of death at 90 days (51% vs. 43%) and increased need for renal-replacement therapy compared to Ringer's acetate.
Transfusion Strategies for Acute Upper Gastrointestinal Bleeding
New England Journal of Medicine · 2013 · Q1 · SJR 18.00 · FWCI 106.86 · 1,729 citations · Open access
A restrictive red blood cell transfusion strategy (hemoglobin <7 g/dL) significantly improved 6-week survival by 4% (95% vs. 91%) and reduced re-bleeding and adverse events compared to a liberal strategy (hemoglobin <9 g/dL) in 921 patients with acute upper gastrointestinal bleeding.
Death on the battlefield (2001–2011)
The Journal of Trauma: Injury, Infection, and Critical Care · 2012 · Q1 · SJR 1.00 · FWCI 37.25 · 1,693 citations
Over 4,500 battlefield fatalities from 2001-2011 revealed that 87.3% died before reaching medical facilities, with 24.3% of these pre-facility deaths deemed potentially survivable.
Hydroxyethyl Starch or Saline for Fluid Resuscitation in Intensive Care
New England Journal of Medicine · 2012 · Q1 · SJR 18.00 · FWCI 107.61 · 1,690 citations · Open access
In ICU patients, 6% hydroxyethyl starch (HES) did not significantly differ from saline in 90-day mortality, but HES was linked to more renal-replacement therapy treatments.
Stroke-Associated Pneumonia: Major Advances and Obstacles
Cerebrovascular Diseases · 2013 · Q2 · FWCI 51.83 · 1,661 citations · Open access
Stroke-associated pneumonia (SAP) is a significant complication after acute ischemic stroke, costing the US nearly $459 million annually and contributing to increased morbidity and mortality.
Antimicrobial-Resistant Pathogens Associated with Healthcare-Associated Infections Summary of Data Reported to the National Healthcare Safety Network at the Centers for Disease Control and Prevention, 2009–2010
Infection Control and Hospital Epidemiology · 2012 · Q1 · FWCI 60.12 · 1,586 citations
In 2009-2010, multidrug-resistant gram-negative bacteria were reported from a moderate proportion of hospitals experiencing healthcare-associated infections (HAIs), despite overall resistance patterns remaining similar to previous years.
The European guideline on management of major bleeding and coagulopathy following trauma: fourth edition
Critical Care · 2016 · Q1 · SJR 3.00 · FWCI 138.03 · 1,480 citations · Open access
The fourth edition of the European guideline for trauma bleeding management recommends direct transfer to trauma centers and a restricted fluid resuscitation strategy, alongside a goal-directed approach for blood product use.
Postdischarge symptoms and rehabilitation needs in survivors of COVID‐19 infection: A cross‐sectional evaluation
Journal of Medical Virology · 2020 · Q1 · SJR 1.00 · FWCI 142.60 · 1,468 citations · Open access
A study of 100 COVID-19 survivors found that a significant majority experienced new fatigue (up to 72%), breathlessness (up to 65.6%), and psychological distress (up to 46.9%) four to eight weeks after hospital discharge.
Balanced Crystalloids versus Saline in Critically Ill Adults
New England Journal of Medicine · 2018 · Q1 · SJR 18.00 · FWCI 96.94 · 1,419 citations · Open access
In critically ill adults, administering balanced crystalloids instead of saline for intravenous fluids led to a 1.1 percentage point reduction in major adverse kidney events within 30 days, a composite outcome including death, new renal-replacement therapy, or persistent renal dysfunction.
International ERS/ESICM/ESCMID/ALAT guidelines for the management of hospital-acquired pneumonia and ventilator-associated pneumonia
European Respiratory Journal · 2017 · Q1 · SJR 5.00 · FWCI 50.86 · 1,408 citations · Open access
New international guidelines for hospital-acquired pneumonia (HAP) and ventilator-associated pneumonia (VAP) have been developed, updating recommendations based on a decade of new research and clinical trials.
Albumin Replacement in Patients with Severe Sepsis or Septic Shock
New England Journal of Medicine · 2014 · Q1 · SJR 18.00 · FWCI 73.52 · 1,321 citations · Open access
In patients with severe sepsis or septic shock, administering 20% albumin alongside crystalloid solutions did not improve survival rates at 28 or 90 days compared to crystalloid solution alone.
Recently added
The European guideline on management of major bleeding and coagulopathy following trauma: sixth edition
Critical Care · 2023 · Q1 · SJR 3.00 · FWCI 130.89 · 724 citations · Open access
The 6th edition of the European guideline offers 39 evidence-based recommendations for managing major bleeding and coagulopathy in trauma patients, aiming to reduce preventable deaths.
Postdischarge symptoms and rehabilitation needs in survivors of COVID‐19 infection: A cross‐sectional evaluation
Journal of Medical Virology · 2020 · Q1 · SJR 1.00 · FWCI 142.60 · 1,468 citations · Open access
A study of 100 COVID-19 survivors found that a significant majority experienced new fatigue (up to 72%), breathlessness (up to 65.6%), and psychological distress (up to 46.9%) four to eight weeks after hospital discharge.
Deep Learning for Classification and Localization of COVID-19 Markers in Point-of-Care Lung Ultrasound
IEEE Transactions on Medical Imaging · 2020 · Q1 · SJR 2.00 · FWCI 54.82 · 613 citations
A novel deep network, derived from Spatial Transformer Networks, simultaneously predicts COVID-19 severity scores and localizes pathological artifacts in lung ultrasound (LUS) images using weakly-supervised learning.
Proposal for International Standardization of the Use of Lung Ultrasound for Patients With <scp>COVID</scp>‐19
Journal of Ultrasound in Medicine · 2020 · Q2 · FWCI 61.77 · 622 citations
A proposed standardized approach for using lung ultrasound in COVID-19 patients, covering equipment, procedure, classification, and data sharing, aims to optimize its application amidst the global pandemic.
Prevalence and Outcomes of Infection Among Patients in Intensive Care Units in 2017
JAMA · 2020 · Q1 · SJR 5.00 · FWCI 57.08 · 1,028 citations · Open access
A 2017 global study found 54% of ICU patients had suspected or proven infections, with a 30% in-hospital mortality rate for infected patients.
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