Oral Diseases· 2026Q1
DNA Adducts, Chromosomal Instability, EMT , and GSTM1 in Oral Squamous Cell Carcinoma
- 0citations
- Q1SCImago
- 2026year
Short summary
Nodal positivity (HR 3.84) and Stage IV disease (HR 7.82) were the sole independent predictors of survival in oral squamous cell carcinoma (OSCC) patients (n=160), while DNA adducts, chromosomal instability, EMT, and GSTM1 genotype showed no independent prognostic value.
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Key points
- Nodal positivity (HR 3.84) and Stage IV disease (HR 7.82) independently predicted poorer survival in OSCC patients (n=160).
- DNA adduct burden and EMT score were highly correlated (r=0.923) but did not independently predict advanced stage or survival.
- Chromosomal instability and GSTM1 genotype also lacked independent prognostic value for advanced stage or survival.
- A combined clinical-molecular model achieved a modest AUC of 0.689 for survival prediction.
AI-generated from the title and abstract; the full text is not read.
Abstract
ABSTRACT Purpose To determine whether DNA‐adduct burden, chromosomal instability, epithelial‐mesenchymal transition, and glutathione S‐transferase M1 (GSTM1) genotype are independently associated with advanced‐stage oral squamous cell carcinoma or overall survival. Methods We studied 160 patients with histologically confirmed oral squamous cell carcinoma. DNA‐adduct burden was measured by 32P‐postlabeling, validated against mass spectrometry in 50 patients; chromosomal instability by fluorescence in situ hybridization of chromosomes 7, 9, and 11; epithelial‐mesenchymal transition by E‐cadherin/vimentin immunohistochemistry; and GSTM1 genotype by multiplex polymerase chain reaction. Logistic and Cox regression were performed. Results DNA‐adduct burden and epithelial‐mesenchymal transition score were strongly correlated ( r = 0.923, p < 0.001), but neither differed by tumor stage. None of the four markers was independently associated with advanced‐stage disease. During follow‐up, 48 patients died. Nodal positivity (hazard ratio 3.84, 95% confidence interval 2.00–7.38, p < 0.001) and Stage IV disease (hazard ratio 7.82, 95% confidence interval 2.12–28.84, p = 0.002) were independently associated with poorer survival. The combined clinical‐molecular model showed modest discrimination (AUC 0.689). Conclusion Nodal status and advanced stage were the dominant independent determinants of survival, with routine nodal assessment improving prognostic discrimination beyond stage alone. The four molecular markers tracked with disease characteristics but added no independent prognostic value, warranting replication in larger, prospective cohorts.
The authors' abstract, as published at the source. Oral Diseases, 2026 · DOI ↗
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Field: Otorhinolaryngology
OtorhinolaryngologyMedicine