Scientific Reports· 2026Q1
Complementary and alternative natural medicinal agents accelerate skin wound healing effectively through modulating the pathological outcomes in rat model
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- 2026year
Short summary
Chitosan treatment significantly accelerated skin wound healing in rats by the 14th day, outperforming stem cells, Aloe vera, and hyaluronic acid, as evidenced by superior wound contraction and higher tissue growth/immune markers.
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Key points
- Chitosan treatment resulted in the fastest wound contraction rate by day 14 in a rat model.
- Stem cells showed the fastest wound contraction on days 3 and 7, followed closely by chitosan.
- Chitosan treatment led to the highest levels of tissue growth and immune markers on day 14.
- The study utilized wound diameter measurements, immunohistochemistry, and histopathology for evaluation.
AI-generated from the title and abstract; the full text is not read.
Abstract
Abstract Some alternative natural therapeutic agents have a significant role in accelerating the healing of wounded skin to minimize potential complications such as infection and to improve the process of regeneration. An experimental study was conducted on seventy male rats divided equally into five groups and sustained circular skin wounds, only four groups were treated with Aloe vera gel, stem cells, chitosan and hyaluronic acid respectively. The assessment of the healing acceleration process underwent several diverse techniques. After precise follow-up and measurement of the induced wound diameters on the third, seventh and fourteenth days, as well as the immunohistochemistry and histopathological evaluation, results of Improved healing process in treated groups were fully demonstrated and expressed through photomicrographs and charts of pathological alterations, some tissue growth markers and immune markers in fixed tissue. Our wound contraction rate measurements showed that the stem cells treated—group led on the third and seventh days, followed by the chitosan—treated, group with no significant difference. However, the chitosan-treated group outperformed all other experimental groups by the fourteenth day. Both tissue growth markers and immune markers on the fourteenth day showed the highest values in chitosan treated group followed by the stem cells—treated group.
The authors' abstract, as published at the source. Scientific Reports, 2026 · DOI ↗
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Field: Rehabilitation
RehabilitationMedicine