Key papers in Rehabilitation
Pofolia’s corpus holds 83 papers from the Rehabilitation subfield (2005–2026). The list below starts with the most cited.
Most cited
Ranked by citation count. Because citations accumulate over time, this list naturally leans towards work published a few years ago; for where the field is now, see “recently added”.
Re-epithelialization and immune cell behaviour in an ex vivo human skin model
Scientific Reports · 2020 · Q1 · FWCI 742.50 · 8,289 citations · Open access
Researchers developed a novel ex vivo human skin wound model using negative pressure, which successfully recapitulates epidermal regeneration and immune cell dynamics observed in natural wound healing.
Wound repair and regeneration: Mechanisms, signaling, and translation
Science Translational Medicine · 2014 · Q1 · SJR 7.00 · FWCI 71.30 · 3,449 citations
Current therapies for poor wound healing are limited due to a poor understanding of the underlying cellular and molecular mechanisms. This review highlights emerging concepts in tissue repair and regeneration to guide clinical translation.
Guidelines for Adult Stroke Rehabilitation and Recovery
Stroke · 2016 · Q1 · SJR 2.00 · FWCI 153.73 · 3,135 citations · Open access
This guideline synthesizes best clinical practices for adult stroke rehabilitation, emphasizing the critical role of sustained, coordinated, multidisciplinary team efforts for maximizing patient recovery and functional independence.
Functional Hydrogels as Wound Dressing to Enhance Wound Healing
ACS Nano · 2021 · Q1 · SJR 4.00 · FWCI 194.30 · 2,972 citations
This review comprehensively summarizes the advanced functions and strategies of hydrogel-based wound dressings, highlighting their potential to enhance wound healing.
Wound Healing: A Cellular Perspective
Physiological Reviews · 2018 · Q1 · SJR 11.00 · FWCI 63.48 · 2,924 citations · Open access
Recent advances in single-cell technologies are revealing unprecedented detail about the diverse cell types and their dynamic interactions crucial for wound healing.
Challenges in the Treatment of Chronic Wounds
Advances in Wound Care · 2015 · Q1 · SJR 1.00 · FWCI 62.26 · 2,580 citations · Open access
Chronic wounds like diabetic foot ulcers present significant challenges due to complex pathophysiology, often failing to heal with standard care within 4 weeks. A systematic reassessment and consideration of advanced therapies are crucial when healing is delayed.
International Journal of Molecular Medicine
International Journal of Molecular Medicine · 2026 · Q1 · SJR 1.00 · 2,254 citations
Subcutaneous pretreatment with a combination of VEGF, bFGF, and PdGF significantly accelerated wound closure and improved mechanical strength and vessel density in mouse skin wounds.
Chronic Wound Healing: A Review of Current Management and Treatments
Advances in Therapy · 2017 · Q1 · SJR 1.00 · FWCI 92.45 · 2,080 citations · Open access
This review synthesizes current knowledge on the complex process of wound healing and the challenges posed by chronic, non-healing wounds.
Transition from inflammation to proliferation: a critical step during wound healing
Cellular and Molecular Life Sciences · 2016 · Q1 · SJR 2.00 · FWCI 55.56 · 1,906 citations · Open access
The transition from the inflammatory to the proliferative phase is a critical, yet poorly understood, step in normal wound healing, and its compromise is linked to chronic wound disorders.
Wound Repair and Regeneration
European Surgical Research · 2012 · Q2 · FWCI 47.56 · 1,879 citations · Open access
This review distinguishes between skin repair, which results in scar formation via fibrosis, and regeneration, which involves the precise substitution of tissue like the epidermis. It outlines the classical phases of acute wound healing: hemostasis, inflammation, proliferation, and maturation.
Wound healing: cellular mechanisms and pathological outcomes
Open Biology · 2020 · Q1 · SJR 1.00 · FWCI 60.94 · 1,731 citations · Open access
This review synthesizes the cellular events crucial for efficient tissue repair and explores how their derangement, particularly in conditions like diabetes and aging, leads to chronic, non-healing wounds.
Wound healing - A literature review
Anais Brasileiros de Dermatologia · 2016 · Q2 · FWCI 45.48 · 1,579 citations · Open access
This review synthesizes the sequential molecular and cellular events involved in skin wound healing, detailing the exudative, proliferative, and remodeling phases.
Epithelialization in Wound Healing: A Comprehensive Review
Advances in Wound Care · 2014 · Q1 · SJR 1.00 · FWCI 39.89 · 1,533 citations
This review synthesizes current knowledge on epithelialization, the critical process of skin regeneration in wound healing, aiming to inform the development of new therapies.
The Role of Macrophages in Acute and Chronic Wound Healing and Interventions to Promote Pro-wound Healing Phenotypes
Frontiers in Physiology · 2018 · Q2 · SJR 1.00 · FWCI 74.08 · 1,515 citations · Open access
Macrophages are central to wound healing, shifting from pro-inflammatory to anti-inflammatory roles as wounds resolve. In chronic wounds, macrophages remain stuck in a pro-inflammatory state, hindering healing.
Physical Activity and Exercise Recommendations for Stroke Survivors
Stroke · 2014 · Q1 · SJR 2.00 · FWCI 65.02 · 1,511 citations
This scientific statement provides updated evidence-based recommendations for physical activity and exercise for stroke survivors, emphasizing its crucial role in management and recovery.
Wound dressings – a review
Biomedicine · 2015 · Q2 · FWCI 27.94 · 1,505 citations
This review traces the historical development of wound dressings from their origins to the present day, highlighting over 3000 products designed to target various aspects of the complex wound healing process.
Extracellular Matrix Reorganization During Wound Healing and Its Impact on Abnormal Scarring
Advances in Wound Care · 2013 · Q1 · SJR 1.00 · FWCI 7.02 · 1,429 citations
Understanding how extracellular matrix (ECM) components reorganize during wound healing is key to developing therapies for preventing hypertrophic and keloid scars.
Post-Stroke Fatigue: Epidemiology, Clinical Characteristics and Treatment
European Neurology · 2014 · Q2 · FWCI 92.34 · 1,419 citations
Fatigue is a common, disabling, and persistent symptom in stroke survivors, significantly worsening outcomes and predicting mortality.
Reactive oxygen species (ROS) and wound healing: the functional role of ROS and emerging ROS‐modulating technologies for augmentation of the healing process
International Wound Journal · 2015 · Q1 · FWCI 21.03 · 1,339 citations
Reactive oxygen species (ROS) are crucial signaling molecules and defense mechanisms in normal wound healing, coordinating immune cell activity, blood vessel formation, and pathogen destruction.
Inflammation and metabolism in tissue repair and regeneration
Science · 2017 · Q1 · SJR 10.00 · FWCI 59.71 · 1,327 citations
This review synthesizes current understanding of how inflammation and cell metabolism orchestrate tissue repair, highlighting how dysregulation leads to fibrosis and impaired function.
Recently added
Interleukin-6 in acute exercise and training: what is the biological relevance?
PubMed · 2026 · FWCI 8.41 · 832 citations
Contracting skeletal muscles are the primary source of the significant increase in Interleukin-6 (IL-6) observed during prolonged, intense exercise, influencing immune and metabolic responses.
Characterization of inflammatory responses to eccentric exercise in humans
PubMed · 2026 · FWCI 30.01 · 501 citations
Eccentric exercise triggers muscle damage, characterized by inflammation, leukocyte infiltration, and cytokine release, with responses varying by exercise type, prior loading, age, and sex.
Leucocytes, cytokines and satellite cells: what role do they play in muscle damage and regeneration following eccentric exercise?
PubMed · 2026 · FWCI 5.00 · 576 citations
Eccentric exercise causes muscle damage and inflammation, with severe protocols leading to prolonged recovery (>1 week) versus mild damage from regular training recovering within days.
Changes in inflammatory mediators following eccentric exercise of the elbow flexors
PubMed · 2026 · FWCI 20.00 · 312 citations
Repeated eccentric elbow flexor exercise in untrained males led to significantly smaller muscle damage markers (soreness, swelling, CK, Mb) after a second bout compared to the first, indicating adaptation. Despite muscle damage, plasma cytokine concentrations showed only minor changes, suggesting eccentric exercise-induced damage is not strongly linked to systemic cytokine release.
Eccentric exercise-induced delayed-onset muscle soreness and changes in markers of muscle damage and inflammation
PubMed · 2026 · FWCI 5.00 · 200 citations
Eccentric exercise led to peak muscle soreness (VAS) at 72h, with serum myoglobin (Mb) also peaking at 72h and correlating with soreness (r=0.73). Neutrophil counts and migratory activity increased significantly by 4h post-exercise, suggesting their mobilization and migration into muscle tissue contribute to damage and inflammation.
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