Advances in Laboratory Medicine / Avances en Medicina de Laboratorio· 2026Q2
Practical recommendations for the implementation of the Kidney Failure Risk Equation in a clinical laboratory setting
- 0citations
- Q2SCImago
- 2026year
Short summary
Clinical laboratories can now standardize the implementation of the Kidney Failure Risk Equation (KFRE) with new consensus recommendations from SEMEDLAB, addressing key methodological questions on eGFR equations, biomarkers, and reporting.
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Key points
- New consensus recommendations from SEMEDLAB offer standardized guidance for laboratory implementation of the KFRE.
- The recommendations cover crucial aspects such as eGFR equation selection, choice of biomarkers (creatinine, cystatin C), and albuminuria measurement.
- Standardized reporting practices are detailed to ensure consistent KFRE results.
- The goal is to improve risk stratification and patient care for individuals with CKD.
AI-generated from the title and abstract; the full text is not read.
Abstract
Abstract The Kidney Failure Risk Equation (KFRE) is a validated tool for predicting the risk of kidney failure in patients with chronic kidney disease (CKD) and is increasingly recommended to guide referral pathways, monitoring, and treatment decisions. As its clinical use expands, laboratories play a central role in ensuring accurate, standardized, and harmonized implementation. However, important methodological questions remain regarding the selection of estimated glomerular filtration rate (eGFR) equations, additional laboratory biomarkers, reporting practices, and analytical considerations, while current guidance remains heterogeneous. This document reviews the available evidence and international guidance on the laboratory implementation of the KFRE, with a particular focus on eGFR equations, creatinine and cystatin C, albuminuria measurement, measured GFR, analytical performance, and reporting considerations. Based on this evidence, the Nephrology Commission of the Spanish Society of Laboratory Medicine (SEMEDLAB) presents consensus recommendations for standardized implementation of the KFRE in routine clinical laboratory practice. By distinguishing the available evidence from expert consensus, this document aims to support harmonized laboratory practice, facilitate consistent KFRE reporting, and promote reliable risk stratification to improve the care of patients with CKD.
The authors' abstract, as published at the source. Advances in Laboratory Medicine / Avances en Medicina de Laboratorio, 2026 · DOI ↗
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Field: Nephrology
NephrologyMedicine