Key papers in Nephrology
Pofolia’s corpus holds 54 papers from the Nephrology subfield (2012–2024). The list below starts with the most cited.
Most cited
Ranked by citation count. Because citations accumulate over time, this list naturally leans towards work published a few years ago; for where the field is now, see “recently added”.
KDIGO Clinical Practice Guidelines for Acute Kidney Injury
Nephron Clinical Practice · 2012 · FWCI 108.55 · 8,036 citations
The KDIGO guidelines provide a framework for managing acute kidney injury (AKI), categorizing recommendations by strength and quality of evidence.
Global, regional, and national burden of chronic kidney disease, 1990–2017: a systematic analysis for the Global Burden of Disease Study 2017
The Lancet · 2020 · FWCI 416.79 · 6,646 citations · Open access
Chronic kidney disease (CKD) caused 1.2 million deaths globally in 2017, with the all-age mortality rate increasing by 41.5% since 1990, while the age-standardized rate remained stable.
Regulation of the Voltage Gated K<sup>+</sup> Channel K<sub>v1.3</sub> by Recombinant Human Klotho Protein
Kidney & Blood Pressure Research · 2014 · Q2 · FWCI 56.45 · 5,609 citations · Open access
Recombinant human Klotho protein significantly enhances Kv1.3 channel abundance and currents in cell membranes, an effect dependent on Klotho's beta-glucuronidase activity.
Management of Chronic Kidney Disease Patients in the Intensive Care Unit: Mixing Acute and Chronic Illness
Blood Purification · 2017 · Q2 · FWCI 265.72 · 5,017 citations · Open access
Critically ill patients with chronic kidney disease (CKD) often experience acute kidney injury on top of their chronic condition (AoC), accelerating progression to end-stage kidney disease (ESKD). An integrated, multidisciplinary approach is crucial for managing these complex patients.
Differential Diagnosis of Glomerular Disease: A Systematic and Inclusive Approach
American Journal of Nephrology · 2013 · Q1 · SJR 1.00 · FWCI 156.48 · 4,380 citations · Open access
This work introduces systematic diagnostic algorithms based on quantitative measures to aid clinicians in the differential diagnosis of glomerular disease, addressing key questions about biopsy timing and treatment.
New Creatinine- and Cystatin C–Based Equations to Estimate GFR without Race
New England Journal of Medicine · 2021 · Q1 · SJR 18.00 · FWCI 295.25 · 4,150 citations · Open access
New equations estimating glomerular filtration rate (eGFR) have been developed using creatinine and cystatin C levels, omitting race as a factor. These new equations demonstrate improved accuracy and reduced disparities between Black and non-Black individuals compared to existing race-inclusive formulas.
Estimating Glomerular Filtration Rate from Serum Creatinine and Cystatin C
New England Journal of Medicine · 2012 · Q1 · SJR 18.00 · FWCI 97.35 · 4,077 citations · Open access
A new equation combining serum creatinine and cystatin C estimates glomerular filtration rate (GFR) more accurately and precisely than equations using either marker alone, potentially reducing chronic kidney disease overdiagnosis.
Global Prevalence of Chronic Kidney Disease – A Systematic Review and Meta-Analysis
PLoS ONE · 2016 · Q1 · FWCI 53.91 · 4,026 citations · Open access
This meta-analysis estimates the global prevalence of Chronic Kidney Disease (CKD) at 13.4%, with a significant portion (10.6%) in stages 3-5, indicating a widespread health issue.
Evaluation and Management of Chronic Kidney Disease: Synopsis of the Kidney Disease: Improving Global Outcomes 2012 Clinical Practice Guideline
Annals of Internal Medicine · 2013 · Q1 · SJR 2.00 · FWCI 59.09 · 3,637 citations
This synopsis presents 10 key recommendations from the 2012 KDIGO clinical practice guidelines for evaluating, classifying, monitoring, and managing chronic kidney disease (CKD) in adults not on renal replacement therapy.
Diagnosis, evaluation, and management of acute kidney injury: a KDIGO summary (Part 1)
Critical Care · 2013 · Q1 · SJR 3.00 · FWCI 40.93 · 2,838 citations · Open access
This review summarizes key aspects of the 2012 KDIGO clinical practice guideline for Acute Kidney Injury (AKI), focusing on its definition, staging, evaluation, and non-dialytic management.
Diabetic Kidney Disease
Clinical Journal of the American Society of Nephrology · 2017 · Q1 · SJR 2.00 · FWCI 60.58 · 2,798 citations · Open access
Diabetic kidney disease affects 40% of diabetic patients, leading to ESRD and increased cardiovascular mortality, yet current therapies leave a significant residual risk.
Dialysis Dose and Intradialytic Hypotension: Results from the HEMO Study
American Journal of Nephrology · 2013 · Q1 · SJR 1.00 · FWCI 103.99 · 2,699 citations · Open access
A higher dialysis dose (higher Kt/V) is associated with an increased risk of intradialytic hypotension (IDH) requiring intervention in chronic hemodialysis patients.
Obesity and Kidney Disease: Hidden Consequences of the Epidemic
American Journal of Nephrology · 2017 · Q1 · SJR 1.00 · FWCI 149.35 · 2,222 citations · Open access
Obesity is a growing epidemic with significant implications for kidney health, acting as a strong risk factor for chronic kidney disease and other renal issues.
Acute Kidney Injury and Chronic Kidney Disease as Interconnected Syndromes
New England Journal of Medicine · 2014 · Q1 · SJR 18.00 · FWCI 62.41 · 1,955 citations
Acute and chronic kidney diseases are not separate conditions but are deeply intertwined, challenging the traditional view of kidney disease.
Chronic Kidney Disease Diagnosis and Management
JAMA · 2019 · Q1 · SJR 5.00 · FWCI 66.60 · 1,755 citations
Chronic kidney disease (CKD), affecting 8%-16% globally and often unrecognized by patients, requires primary care screening and management to prevent severe outcomes like cardiovascular disease and death.
A Study to Evaluate Psychological Distress and Self-Esteem Among Patients with Hemodialysis
International Journal of Innovative Science and Research Technology (IJISRT) · 2024 · FWCI 503.81 · 1,745 citations
In a study of 30 hemodialysis patients, nearly half experienced some level of psychological distress, with 16.7% reporting severe distress. Additionally, 27% of patients exhibited low or below-average self-esteem.
Acute kidney disease and renal recovery: consensus report of the Acute Disease Quality Initiative (ADQI) 16 Workgroup
Nature Reviews Nephrology · 2017 · Q1 · SJR 10.00 · FWCI 57.58 · 1,539 citations · Open access
This consensus report introduces definitions, staging criteria, and management strategies for acute kidney disease (AKD), a condition describing the period after acute kidney injury (AKI).
2012 American College of Rheumatology guidelines for management of gout. Part 1: Systematic nonpharmacologic and pharmacologic therapeutic approaches to hyperuricemia
Arthritis Care & Research · 2012 · Q1 · SJR 1.00 · FWCI 52.68 · 1,538 citations · Open access
This document presents the 2012 American College of Rheumatology (ACR) guidelines for managing gout, focusing on nonpharmacologic and pharmacologic strategies to treat hyperuricemia.
World Incidence of AKI
Clinical Journal of the American Society of Nephrology · 2013 · Q1 · SJR 2.00 · FWCI 26.24 · 1,461 citations · Open access
A systematic review of over 49 million patients reveals that 1 in 5 adults and 1 in 3 children globally experience Acute Kidney Injury (AKI) during a hospital stay, with higher mortality in children.
Analysis of the Global Burden of Disease study highlights the global, regional, and national trends of chronic kidney disease epidemiology from 1990 to 2016
Kidney International · 2018 · Q1 · SJR 5.00 · FWCI 46.04 · 1,443 citations
Chronic kidney disease (CKD) incidence and prevalence surged globally between 1990 and 2016, with incidence rising 89% and prevalence 87%. This increase is primarily driven by population growth and aging, but in some regions, diabetes and hypertension are significant contributing factors.
Recently added
A Study to Evaluate Psychological Distress and Self-Esteem Among Patients with Hemodialysis
International Journal of Innovative Science and Research Technology (IJISRT) · 2024 · FWCI 503.81 · 1,745 citations
In a study of 30 hemodialysis patients, nearly half experienced some level of psychological distress, with 16.7% reporting severe distress. Additionally, 27% of patients exhibited low or below-average self-esteem.
A Synopsis of the Evidence for the Science and Clinical Management of Cardiovascular-Kidney-Metabolic (CKM) Syndrome: A Scientific Statement From the American Heart Association
Circulation · 2023 · Q1 · SJR 8.00 · FWCI 174.24 · 1,144 citations · Open access
The American Heart Association defines Cardiovascular-Kidney-Metabolic (CKM) syndrome, highlighting its pathophysiology linking metabolic risk factors, chronic kidney disease, and cardiovascular disease, and outlining current evidence and critical knowledge gaps in its management.
New Creatinine- and Cystatin C–Based Equations to Estimate GFR without Race
New England Journal of Medicine · 2021 · Q1 · SJR 18.00 · FWCI 295.25 · 4,150 citations · Open access
New equations estimating glomerular filtration rate (eGFR) have been developed using creatinine and cystatin C levels, omitting race as a factor. These new equations demonstrate improved accuracy and reduced disparities between Black and non-Black individuals compared to existing race-inclusive formulas.
Chronic kidney disease
The Lancet · 2021 · FWCI 108.39 · 1,407 citations
A plant-dominant, low-protein, low-salt diet may preserve kidney function by mitigating glomerular hyperfiltration and improving acid-base balance and gut microbiome, while pharmacotherapies like RAAS inhibitors and SGLT2 inhibitors reduce intraglomerular pressure, and MRAs offer anti-inflammatory/antifibrotic protection.
Diabetic Nephropathy: Challenges in Pathogenesis, Diagnosis, and Treatment
BioMed Research International · 2021 · Q2 · FWCI 76.83 · 966 citations · Open access
Diabetic nephropathy (DN) continues to increase despite standard therapies, with challenges in diagnosing and treating nonproteinuric DN (NP-DN) and a need for novel treatments targeting inflammation and oxidative stress.
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