Frontiers in Neuroscience· 2026Q2· Review
Microglia in the neurogenic niche: emerging roles of immunometabolism
- 0citations
- Q2SCImago
- 2026year
Short summary
Microglia, influenced by their immunometabolic state, actively remodel the neurogenic niche, linking brain pathology to neurogenesis decline.
AI-generated from the title and abstract; the full text is not read.
Key points
- Adult neurogenesis is regulated by the neurogenic niche, but mechanisms are not fully understood.
- Microglia are increasingly recognized as important regulators of the neurogenic niche.
- Immunometabolism influences microglial functional states and their role in niche remodeling.
- Microglial immunometabolic states may link brain pathology to neurogenic niche remodeling.
AI-generated from the title and abstract; the full text is not read.
Abstract
Adult neurogenesis is dynamically regulated by the neurogenic niche, yet the mechanisms governing its remodeling are not fully elucidated. Current research has increasingly extended beyond the intrinsic properties of neural stem cells to consider the broader microenvironment in which neurogenesis occurs, with microglia emerging as important regulators of the neurogenic niche. Drawing upon pathological contexts such as depression and aging, this review characterizes the hallmarks of neurogenic niche dysregulation and synthesizes the mechanisms by which microglia modulate neurogenic efficiency. Particular emphasis is placed on the role of immunometabolism in shaping microglial functional states and subsequent niche remodeling. We propose that microglial immunometabolic states may serve as an important interface through which pathological perturbations within the brain are linked to remodeling of the neurogenic niche, providing a conceptual framework for understanding neurogenic decline across distinct pathological contexts.
The authors' abstract, as published at the source. Frontiers in Neuroscience, 2026 · DOI ↗
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Field: Developmental Neuroscience
Developmental NeuroscienceNeuroscience