Life· 2026Q1
Effects of Dietary Sulforaphane Supplementation on Growth Performance, Intestinal Digestive Capacity, Barrier Function and Appetite-Regulating Gene Expression in Cyprinus carpio haematopterus
- 0citations
- Q1SCImago
- 2026year
Short summary
Supplementing fish diets with 9.71 mg/kg of sulforaphane (SFN) significantly improved growth, intestinal digestive capacity, and barrier function, with optimal effects seen up to 10 mg/kg SFN.
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Key points
- SFN supplementation up to 10 mg/kg diet significantly increased fish growth (daily growth coefficient, feed efficiency) and whole-body protein content.
- Intestinal lipase and protease activities, along with key appetite-regulating genes (apelin, orexin, NPY) and barrier function genes (ZO-1, occludin, claudin-2/3), were enhanced by SFN up to 10 mg/kg.
- Doses exceeding 10 mg/kg SFN led to a decline in these beneficial effects.
- Optimal SFN supplementation level for daily growth coefficient was determined to be 9.71 mg/kg diet via quadratic regression.
AI-generated from the title and abstract; the full text is not read.
Abstract
An 8-week nutrition experiment was carried out to research the role of sulforaphane (SFN) supplementation on growth, intestinal digestive capacity, intestinal barrier function and appetite-regulating gene expressions in Cyprinus carpio haematopterus. Fish (76.17 ± 0.23 g) were fed five experimental diets (namely, S1-5) containing 0, 5, 10, 15 and 20 mg kg−1 of SFN, respectively. Results showed that daily growth coefficient (DGC), growth rate per metabolic body weight, feed efficiency ratio, whole-body crude protein contents, intestinal lipase and protease activities, and expression of apelin, orexin and neuropeptide Y in brain, as well as mammalian target of rapamycin, zonula occludens 1, occludin, claudin-2 and claudin-3 in the intestine increased significantly as SFN levels increased in a 10 mg kg−1 diet, but decreased with further increasing SFN levels. Overall, SFN supplementation improves growth, appetite-regulating gene expressions, intestinal digestive capacity and barrier-related gene expressions of fish. Based on the quadratic regression analysis of DGC against SFN levels, optimal SFN was established to be a 9.71 mg kg−1 diet.
The authors' abstract, as published at the source. Life, 2026 · DOI ↗
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Field: Aquatic Science
Aquatic ScienceAgricultural and Biological Sciences