The Journal of Physical Chemistry B· 2026Q1
Modulating Squaraine Fluorescence via Hydrogen Bonding: A Selective Turn-Off Sensor for Thioglycolic Acid
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- Q1SCImago
- 2026year
Short summary
A squaraine-based fluorescent probe selectively detects thioglycolic acid (TGA) by turning off its fluorescence via hydrogen bonding, with a detection limit of ~4 nM.
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Key points
- A squaraine fluorescent probe was designed for selective thioglycolic acid (TGA) detection.
- TGA interaction causes fluorescence quenching via hydrogen bonding, perturbing the probe's excited state.
- The probe has a linear response range of 23.8–77.4 nM and a detection limit of approximately 4 nM.
- The sensor demonstrated selectivity and successfully quantified TGA in commercial hair removal cream samples.
- The probe functions as a molecular logic gate, indicating potential for intelligent sensing applications.
AI-generated from the title and abstract; the full text is not read.
Abstract
Abstract Thioglycolic acid (TGA), a common ingredient in hair removal creams and other industrial formulations, owing to its hazardous nature, necessitates sensitive and selective analytical detection. Herein, we report a symmetrical squaraine-based fluorescent probe for the selective detection of TGA, investigated employing fluorescence spectroscopy, NMR, and density functional theory (DFT) calculations. The probe upon interaction with TGA, undergoes pronounced fluorescence quenching arising from hydrogen-bonding interaction, which perturbs the intramolecular charge-transfer (ICT) excited state. The probe exhibits a linear response over the 23.8–77.4 nM concentration range with a detection limit of approximately 4 nM and demonstrates excellent selectivity toward TGA. Practical applicability was validated by the quantification of TGA in commercial hair removal cream samples. In addition, the probe functions as a molecular logic gate based on its fluorescence response, highlighting its potential for intelligent molecular sensing.
The authors' abstract, as published at the source. The Journal of Physical Chemistry B, 2026 · DOI ↗
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Field: Spectroscopy
SpectroscopyChemistry