The Journal of Biochemistry· 2026Q2· Review
Isoform-specific roles of SKN-1/Nrf in Caenorhabditis elegans longevity via mTOR signaling
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- Q2SCImago
- 2026year
Short summary
Distinct SKN-1/Nrf isoforms in C. elegans regulate longevity through the mTOR pathway, refining our understanding of nutrient and stress signaling in aging.
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Key points
- SKN-1/Nrf is a conserved transcription factor regulating stress responses, detoxification, and aging.
- Distinct SKN-1 isoforms have unique physiological roles.
- SKN-1 regulates longevity, particularly through the mTOR nutrient-sensing pathway.
- Recent advances focus on isoform-specific regulation of these processes.
AI-generated from the title and abstract; the full text is not read.
Abstract
SKN-1, a Cap'n'Collar transcription factor in Caenorhabditis elegans, is a well-established regulator of oxidative stress responses and xenobiotic detoxification. Over the past two decades, the late Dr. T. Keith Blackwell (1957-2025) and colleagues made seminal contributions to defining its biological functions and regulatory mechanisms. Owing to its robust conservation with mammalian Nrf family proteins, SKN-1 research has yielded fundamental insights into how nutrient and stress signals modulate metabolism, proteostasis, and aging. Recently, the discovery that distinct SKN-1 isoforms execute unique physiological roles has further refined this field. In this review, we summarize how SKN-1 regulates longevity, particularly through the mTOR nutrient-sensing pathway, discuss recent advances in isoform-specific regulation, and highlight critical questions for future research.
The authors' abstract, as published at the source. The Journal of Biochemistry, 2026 · DOI ↗
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AgingBiochemistry, Genetics and Molecular Biology