Science· 2026Q1
Whole-body single-cell atlas of an adult vertebrate, Danionella cerebrum
- 6citations
- Q1SCImago
- 2026year
Short summary
A single-cell RNA sequencing atlas of the entire adult Danionella cerebrum body reveals spatially distinct neural cell types, adult molecular positional memory, paedomorphic features, and conserved body-region and appendage-specification programs.
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Key points
- Generated a whole-body single-cell transcriptome atlas of the adult vertebrate Danionella cerebrum.
- Delineated spatially distinct neural cell types using regional gene expression signatures.
- Identified cell types exhibiting adult molecular positional memory.
- Uncovered paedomorphic features and conserved body-region/appendage-specification programs in connective tissue.
- Revealed conserved neural cell types and expression dynamics during telencephalon regeneration.
AI-generated from the title and abstract; the full text is not read.
Abstract
A complete cell type transcriptome atlas of a vertebrate could promote understanding of animal cell type composition, organization, and evolution. The miniaturized, transparent, and regenerative teleost Danionella cerebrum brings whole-vertebrate single-cell profiling experiments within reach. We performed region-stratified single-cell RNA sequencing across the adult Danionella body and mapped cell types and gene expression at single-cell resolution using spatial transcriptomics. We delineated spatially distinct neural cell types on the basis of their regional gene expression signatures. The body-wide atlas elucidated cell types harboring adult molecular positional memory, uncovered paedomorphic features, and revealed conserved body-region and appendage-specification programs in adult connective tissue. Comparative analyses revealed conserved neural cell types, and regeneration datasets uncovered expression dynamics during telencephalon regeneration. This whole-vertebrate transcriptome atlas yields a comprehensive resource for myriad questions in biology and neuroscience.
The authors' abstract, as published at the source. Science, 2026 · DOI ↗
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Field: Molecular Biology
Molecular BiologyBiochemistry, Genetics and Molecular Biology