Angewandte Chemie International Edition· 2026Q1
Proton‐Induced Perthionitrite‐Mediated Zinc Thiolate Persulfidation
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- Q1SCImago
- 2026year
Short summary
Researchers synthesized a zinc perthionitrite complex that acts as both a ligand and a sulfur source, demonstrating that direct S0 transfer from perthionitrite to thiolates is thermodynamically unfavorable and requires preceding perthionitrite decomposition.
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Key points
- A perthiolate-supported zinc perthionitrite complex was synthesized.
- This complex acts as both a ligand to zinc and a sulfur source for thiolate persulfidation.
- Direct S0 transfer from SSNO− to thiolate anions was found to be thermodynamically unfavorable.
- Persulfidation requires preceding SSNO− decomposition.
AI-generated from the title and abstract; the full text is not read.
Abstract
ABSTRACT The perthionitrite anion, SSNO − , has been proposed as a S 0 source for persulfidation of biological thiol and thiolate compounds. Here, SSNO − reacts with an iminopyridine‐supported zinc thiolate complex to form a perthiolate‐supported zinc perthionitrite complex, acting as both a ligand to zinc and as a sulfur source for persulfidation of the thiolate moiety. A related zinc thionitrite complex was also prepared, enabling comparison of zinc thionitrite and zinc thiolate persulfidation. In these compounds, the zinc‐bound SNO − ligand is selectively persulfidated over the zinc‐bound thiolate moiety upon addition of S 8 , cleanly forming SSNO − rather than the perthiolate. This work therefore demonstrates that direct S 0 transfer from SSNO − to thiolate anions is thermodynamically unfavorable and must instead be mediated by preceding SSNO − decomposition.
The authors' abstract, as published at the source. Angewandte Chemie International Edition, 2026 · DOI ↗
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Field: Organic Chemistry
Organic ChemistryChemistry