Nature Metabolism· 2026Q1
Whole-blood NAD levels track cardiovascular disease but not chronological age
- 1citations
- Q1SCImago
- 2026year
Short summary
Whole-blood NAD levels do not decline with age in healthy individuals, but are reduced in chronic diseases, specifically cardiovascular disease and hypertension.
AI-generated from the title and abstract; the full text is not read.
Key points
- Whole-blood NAD levels do not decline with chronological age in healthy adults.
- NAD levels increase in females and remain stable in males with age.
- Chronic diseases, specifically cardiovascular disease and hypertension, are associated with reduced whole-blood NAD levels.
- 1,340 measurements were conducted across 1,068 adults.
AI-generated from the title and abstract; the full text is not read.
Abstract
Abstract The extent to which whole-blood NAD levels are altered in human disease or ageing remains controversial. Here we conducted 1,340 measurements in 1,068 adults, and found that whole-blood NAD levels do not decline with age in healthy individuals; they remain stable in males and increase in females, but are reduced in chronic diseases, specifically cardiovascular disease and hypertension. These findings indicate that whole-blood NAD levels track cardiovascular disease rather than chronological age. As this research was not designed to investigate causality, these data do not provide direct evidence that NAD supplementation may serve as a treatment for cardiovascular disease or hypertension.
The authors' abstract, as published at the source. Nature Metabolism, 2026 · DOI ↗
Continue with a free account
Ask the paper: 3 free questions a day about this paper; save it, get its citation, new summaries every day for your field. Takeaways are Premium.
Continue free on the webSign in with Google or Apple; no card needed. You come back to this paper.
On your phone:
Field: Geriatrics and Gerontology
Geriatrics and GerontologyMedicine