Key papers in Geriatrics and Gerontology
Pofolia’s corpus holds 54 papers from the Geriatrics and Gerontology subfield (2012–2023). The list below starts with the most cited.
Most cited
Ranked by citation count. Because citations accumulate over time, this list naturally leans towards work published a few years ago; for where the field is now, see “recently added”.
What is polypharmacy? A systematic review of definitions
BMC Geriatrics · 2017 · Q1 · SJR 1.00 · FWCI 21.79 · 3,294 citations · Open access
A systematic review found that definitions of polypharmacy, the use of multiple medications, are highly variable and lack consensus, hindering clinical assessment of safety and appropriateness.
American Geriatrics Society 2019 Updated AGS Beers Criteria® for Potentially Inappropriate Medication Use in Older Adults
Journal of the American Geriatrics Society · 2019 · Q1 · SJR 1.00 · FWCI 212.76 · 3,173 citations
The 2019 update to the AGS Beers Criteria® provides an explicit list of medications best avoided by older adults, reflecting the latest evidence reviewed by an expert panel.
Prevalence of Frailty in Community‐Dwelling Older Persons: A Systematic Review
Journal of the American Geriatrics Society · 2012 · Q1 · SJR 1.00 · FWCI 9.17 · 3,110 citations
This systematic review found the overall weighted prevalence of frailty in community-dwelling older adults is 10.7%, but this figure varies significantly (4.0-59.1%) depending on how frailty is defined.
CONSORT 2010 statement: extension to randomised pilot and feasibility trials
Pilot and Feasibility Studies · 2016 · Q2 · FWCI 73.33 · 2,990 citations · Open access
A new extension to the CONSORT statement provides a 26-item checklist and abstract checklist specifically for reporting randomized pilot and feasibility trials.
American Geriatrics Society 2015 Updated Beers Criteria for Potentially Inappropriate Medication Use in Older Adults
Journal of the American Geriatrics Society · 2015 · Q1 · SJR 1.00 · FWCI 186.94 · 2,633 citations
The 2015 AGS Beers Criteria update guidelines for avoiding potentially inappropriate medications in older adults, introducing new lists for kidney function-adjusted dosing and drug-drug interactions associated with harm.
<scp>A</scp> merican <scp>G</scp> eriatrics <scp>S</scp> ociety Updated <scp>B</scp> eers <scp>C</scp> riteria for Potentially Inappropriate Medication Use in Older Adults
Journal of the American Geriatrics Society · 2012 · Q1 · SJR 1.00 · FWCI 137.68 · 2,572 citations
The 2012 American Geriatrics Society Beers Criteria have been updated using a systematic review and expert consensus to identify 53 medications or classes that are potentially inappropriate for older adults.
STOPP/START criteria for potentially inappropriate prescribing in older people: version 2
Age and Ageing · 2014 · Q1 · SJR 2.00 · FWCI 67.19 · 2,402 citations · Open access
The updated STOPP/START version 2 criteria now include 114 guidelines (80 STOPP, 34 START), a 31% increase from the previous version, to better identify and reduce inappropriate medication use in older adults.
Clinical consequences of polypharmacy in elderly
Expert Opinion on Drug Safety · 2013 · Q2 · FWCI 24.64 · 1,906 citations
Polypharmacy, defined as using more medications than medically necessary, is prevalent in older adults, with nearly 50% taking unnecessary drugs, strongly linked to negative clinical outcomes.
International Society of Geriatric Oncology Consensus on Geriatric Assessment in Older Patients With Cancer
Journal of Clinical Oncology · 2014 · Q1 · SJR 4.00 · FWCI 54.41 · 1,811 citations
Geriatric Assessment (GA) is now recommended for older cancer patients to detect impairments, predict treatment toxicity and survival, and guide treatment decisions.
Reducing Inappropriate Polypharmacy
JAMA Internal Medicine · 2015 · Q1 · SJR 4.00 · FWCI 60.57 · 1,526 citations
A proposed 5-step deprescribing protocol aims to reduce inappropriate polypharmacy, particularly in older adults, by systematically tapering or stopping medications with the lowest benefit-harm ratio.
Development and validation of a Hospital Frailty Risk Score focusing on older people in acute care settings using electronic hospital records: an observational study
The Lancet · 2018 · FWCI 49.49 · 1,485 citations · Open access
A new Hospital Frailty Risk Score, derived from ICD-10 codes in electronic health records, effectively identifies older patients at high risk for adverse outcomes like mortality, long hospital stays, and readmissions.
Practical Assessment and Management of Vulnerabilities in Older Patients Receiving Chemotherapy: ASCO Guideline for Geriatric Oncology
Journal of Clinical Oncology · 2018 · Q1 · SJR 4.00 · FWCI 68.59 · 1,434 citations
ASCO now recommends geriatric assessment (GA) for patients aged 65+ receiving chemotherapy to identify vulnerabilities beyond standard oncology evaluations.
Effect of Structured Physical Activity on Prevention of Major Mobility Disability in Older Adults
JAMA · 2014 · Q1 · SJR 5.00 · FWCI 63.73 · 1,419 citations
A structured, moderate-intensity physical activity program reduced major mobility disability by 18% over 2.6 years compared to a health education program in sedentary older adults aged 70-89 at risk for disability.
American Geriatrics Society 2023 updated AGS Beers Criteria® for potentially inappropriate medication use in older adults
Journal of the American Geriatrics Society · 2023 · Q1 · SJR 1.00 · FWCI 196.78 · 1,356 citations · Open access
The 2023 update to the AGS Beers Criteria® provides an expert-reviewed list of medications best avoided by older adults, incorporating new evidence and usability enhancements.
Development and validation of an electronic frailty index using routine primary care electronic health record data
Age and Ageing · 2016 · Q1 · SJR 2.00 · FWCI 46.59 · 1,351 citations · Open access
Researchers developed and validated an electronic frailty index (eFI) using 36 deficits from routine primary care electronic health records, demonstrating its robust predictive ability for mortality, hospitalization, and nursing home admission in older adults.
Resveratrol Ameliorates Aging-Related Metabolic Phenotypes by Inhibiting cAMP Phosphodiesterases
Cell · 2012 · Q1 · SJR 24.00 · FWCI 76.00 · 1,339 citations · Open access
Resveratrol, a compound found in red wine, combats aging-related metabolic issues by blocking specific enzymes (cAMP phosphodiesterases), which raises crucial cellular energy signals.
NAD <sup>+</sup> in aging, metabolism, and neurodegeneration
Science · 2015 · Q1 · SJR 10.00 · FWCI 33.70 · 1,288 citations
Cellular levels of Nicotinamide adenine dinucleotide (NAD+) decline with age, and manipulating its levels may offer a therapeutic strategy for aging and related disorders, especially neurodegenerative diseases.
Frailty and pre-frailty in middle-aged and older adults and its association with multimorbidity and mortality: a prospective analysis of 493 737 UK Biobank participants
The Lancet Public Health · 2018 · Q1 · SJR 8.00 · FWCI 38.49 · 1,281 citations · Open access
Frailty and pre-frailty are significantly associated with increased mortality in adults aged 37-73, even after accounting for multiple long-term conditions and lifestyle factors.
Trends in Prescription Drug Use Among Adults in the United States From 1999-2012
JAMA · 2015 · Q1 · SJR 5.00 · FWCI 58.48 · 1,225 citations · Open access
Between 1999-2000 and 2011-2012, the percentage of US adults using any prescription drugs rose from 51% to 59%, while the prevalence of polypharmacy (using five or more drugs) nearly doubled from 8.2% to 15%.
Searching for an Operational Definition of Frailty: A Delphi Method Based Consensus Statement. The Frailty Operative Definition-Consensus Conference Project
The Journals of Gerontology Series A · 2012 · Q1 · SJR 1.00 · FWCI 28.09 · 1,193 citations · Open access
A Delphi consensus process involving experts identified six key domains for a clinical definition of frailty but failed to agree on specific diagnostic biomarkers.
Recently added
American Geriatrics Society 2023 updated AGS Beers Criteria® for potentially inappropriate medication use in older adults
Journal of the American Geriatrics Society · 2023 · Q1 · SJR 1.00 · FWCI 196.78 · 1,356 citations · Open access
The 2023 update to the AGS Beers Criteria® provides an expert-reviewed list of medications best avoided by older adults, incorporating new evidence and usability enhancements.
The sirtuin family in health and disease
Signal Transduction and Targeted Therapy · 2022 · Q1 · SJR 17.00 · FWCI 81.44 · 802 citations · Open access
Sirtuins (SIRTs), a family of NAD+-dependent deacetylases, regulate key cellular processes like inflammation, metabolism, and apoptosis, making them promising therapeutic targets for diseases including cancer and cardiovascular conditions.
Research and scholarly methods: Semi‐structured interviews
JACCP JOURNAL OF THE AMERICAN COLLEGE OF CLINICAL PHARMACY · 2021 · Q1 · FWCI 34.19 · 817 citations
This narrative review proposes a 7-step framework (7S CARS-SID) for conducting, analyzing, and reporting semi-structured interview data specifically for pharmacy services research.
A scoping review of the Clinical Frailty Scale
BMC Geriatrics · 2020 · Q1 · SJR 1.00 · FWCI 43.34 · 855 citations · Open access
A scoping review of 183 studies found the Clinical Frailty Scale (CFS) is widely used, particularly in hospitalized older adults, and is predictive of outcomes such as mortality (87% of cases), complications (100%), and cognition (94%).
Prevalence of frailty in 62 countries across the world: a systematic review and meta-analysis of population-level studies
Age and Ageing · 2020 · Q1 · SJR 2.00 · FWCI 18.34 · 1,098 citations
A meta-analysis of 240 studies from 62 countries found that frailty prevalence in adults aged 50+ is 12% using physical measures and 24% using deficit accumulation models (frailty index). Pre-frailty affects nearly half of this population.
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