Dünya Ağız Tıbbı Çalıştayı IX: Oral Lökoplaki üzerine müdahale çalışmalarına yönelik bir temel sonuç kümesinin geliştirilmesi: sonuç alanlarının sistematik bir derlemesi

Özet (abstract)

Objectives To identify primary and secondary outcome measures employed in interventional studies on oral leukoplakia (OL). This systematic review is part of the broader "World Workshop on Oral Medicine Outcomes Initiative for the Direction of Research" (WONDER) project, aimed at developing a core outcome set for reporting interventional studies on OL. Study design A systematic search of publications on OL was conducted from 1980 to March 2025, using Ovid MEDLINE, Embase, CENTRAL, CINAHL, and Clinicaltrials.gov databases, in addition to manual searching. Data on outcomes were extracted and categorized according to the Core Outcome Measures in Effectiveness Trials (COMET) taxonomy, and the reported outcome measures were summarized. Results The search identified 6,747 records. After screening and exclusion, 202 studies were included for data extraction. Most studies were conducted in Asia and Europe, with cohort studies (48.5%) and randomized controlled trials (RCT) (23.3%) accounting for almost three quarters of all studies. Clinical response (40.6%), recurrence (22.3%), and malignant transformation (22.3%) were the most frequently reported primary outcomes, while toxicity/adverse events were the most frequent secondary outcomes. Differences in how outcomes were measured and reported across studies were noted, including differences between RCTs and case series. Furthermore, the crucial outcome of OL malignant transformation was only reported in 46.5% of studies and, more specifically, in only 19.1 % (9/47) of RCTs. Conclusions This study highlights the variability in selection and reporting of outcome measures in OL interventional studies. We recommend that, in reporting future interventional studies on OL, authors should clearly highlight the primary and secondary outcome measures used. The ability to synthesis future evidence would be greatly enhanced by the development of a core outcome set for interventional studies on oral leukoplakia.

Yazarların özeti; kaynağından alınmıştır. Oral Surgery Oral Medicine Oral Pathology and Oral Radiology, 2026 · DOI ↗