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Nature· 2026Q1

Advancing regulatory variant effect prediction with AlphaGenome

Natasha S. Latysheva, Natasha S. Latysheva, Jun Cheng, Guido Novati et al.

Short summary

AlphaGenome, a novel deep learning model, predicts thousands of functional genomic tracks from 1 Mb DNA sequences at single-base-pair resolution, outperforming existing models in 25 of 26 evaluations.

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GeneticsBiochemistry, Genetics and Molecular Biology