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Nature· 2025Q1

A skin-permeable polymer for non-invasive transdermal insulin delivery

Qiuyu Wei, Zhimin He, Zifan Li, Zhuxian Zhou et al.

Short summary

A novel polyzwitterion polymer (OP) enables efficient transdermal delivery of insulin into circulation, demonstrated by quickly lowering blood glucose in diabetic mice (116 U kg−1) and minipigs (29 U kg−1).

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Pharmaceutical SciencePharmacology, Toxicology and Pharmaceutics