Pharmaceutical Science papers
Pofolia’s corpus holds 34 papers from Pharmaceutical Science (2025–2026), each with a short summary. Below, the 20 most-cited, then the most recently added.
At a glance
- Most cited: Bridging the Gap: The Role of Advanced Formulation Strategies in the Clinical Translation of Nanoparticle-Based Drug Delivery Systems (2025, 98 citations).
- The 20 papers listed have 423 citations between them.
- 16 of the 20 with a known journal quartile appeared in a Q1 journal.
- 7 have a free full text (open access).
- Most frequent journals: The Journal of Organic Chemistry, Frontiers in Pharmacology, Pharmaceuticals.
- Published between 2025 and 2026.
Most cited
Ranked by citation count. Because citations accumulate over time, this list naturally leans towards work published a few years ago; for where the field is now, see “recently added”. How to read the signals
Bridging the Gap: The Role of Advanced Formulation Strategies in the Clinical Translation of Nanoparticle-Based Drug Delivery Systems
International Journal of Nanomedicine · 2025 · Q1 · SJR 1.00 · FWCI 34.05 · 98 citations · Open access
Advanced formulation strategies, beyond nanoparticle design alone, are critical for translating laboratory-based nanoparticle drug delivery systems into clinical applications, addressing challenges like stability and bioavailability for specific routes of administration.
Machine learning empowered formulation design, optimization and characterization of nanoparticulate drug delivery systems: Current applications, challenges, and future perspectives
Acta Pharmaceutica Sinica B · 2025 · Q1 · SJR 3.00 · FWCI 13.55 · 39 citations
Machine learning (ML) is accelerating the design, optimization, and characterization of nanoparticulate drug delivery systems (NDDS) by predicting critical quality attributes like particle size, encapsulation efficiency, and stability.
A skin-permeable polymer for non-invasive transdermal insulin delivery
Nature · 2025 · Q1 · SJR 19.00 · FWCI 12.51 · 36 citations
A novel polyzwitterion polymer (OP) enables efficient transdermal delivery of insulin into circulation, demonstrated by quickly lowering blood glucose in diabetic mice (116 U kg−1) and minipigs (29 U kg−1).
Mesoporous Silica Nanoparticles as Drug Delivery Systems
Pharmaceuticals · 2025 · Q1 · SJR 1.00 · FWCI 12.57 · 36 citations · Open access
Mesoporous silica nanoparticles (MSNs) stabilize amorphous drugs, improving solubility and protecting against degradation, which enhances bioavailability and enables targeted delivery.
Targeting the Oral Mucosa: Emerging Drug Delivery Platforms and the Therapeutic Potential of Glycosaminoglycans
Pharmaceutics · 2025 · Q1 · SJR 1.00 · FWCI 12.38 · 33 citations · Open access
Glycosaminoglycans (GAGs) show promise for oral mucosa drug delivery, enhancing residence time and enabling controlled release via films, hydrogels, and nanoengineered carriers, potentially enabling precision local and systemic therapies.
Isoliquiritigenin micellar microneedle for pH monitoring and diabetic wound healing
Materials Today Bio · 2025 · Q1 · SJR 1.00 · FWCI 11.12 · 32 citations
pH-responsive hydrogel microneedles (LSI-GCA) loaded with isoliquiritigenin (ISO) enable real-time pH monitoring and intelligent drug release, significantly accelerating diabetic wound healing by promoting angiogenesis and M2 macrophage polarization.
Semiheterogeneous Intrinsic FeTiO3-Photoredox/Ph3N Dual-Catalyzed Fluoroalkylation of N-Heteroarenes with Alkenes and RfSO2Cl
The Journal of Organic Chemistry · 2025 · Q2 · FWCI 11.12 · 32 citations
A new semiheterogeneous method uses intrinsic FeTiO3 as a photocatalyst and Ph3N as a redox mediator to fluoroalkylate N-heteroarenes with alkenes and RfSO2Cl, achieving high yields and functional-group tolerance without sacrificial reagents.
Artificial intelligence and machine learning guided optimization in drug delivery
Advanced Drug Delivery Reviews · 2026 · Q1 · SJR 4.00 · FWCI 31.62 · 32 citations
AI and ML are enabling data-driven, adaptive, and efficient optimization strategies for drug delivery systems, overcoming limitations of traditional methods in complex formulation challenges.
Innovative dual-functional hybrid cationic PEGylated proniosomes as a smart nano-platform for Boosted vaginal delivery: multi-level in-vitro, ex-vivo, microbiological, and in-vivo studies
Frontiers in Pharmacology · 2026 · Q1 · SJR 1.00 · FWCI 111.38 · 29 citations · Open access
A novel Dual-Functional Hybrid Cationic PEGylated Proniosomes (DHCPP) nano-platform significantly enhances vaginal delivery of Fenticonazole Nitrate (FTN), showing a 2.36-fold permeation increase and improved antifungal efficacy.
Oleic acid Enriched Leciplexes as Novel Mucoadhesive Cationic Nanocarriers of Agomelatine for Glaucoma Treatment
AAPS PharmSciTech · 2025 · Q1 · FWCI 9.73 · 28 citations · Open access
Oleic acid-enriched leciplexes (L20) carrying agomelatine (AGO) improved ocular bioavailability 3-fold in rabbits compared to AGO dispersion.
The future of vesicular drug delivery: transferosomes in therapeutic advancement—applications, innovations and challenges
BioMedical Engineering OnLine · 2025 · Q1 · FWCI 9.44 · 27 citations
Transferosomes, ultra-deformable lipid vesicles, facilitate transdermal drug delivery by disrupting the stratum corneum and transporting molecules via a hydration gradient, showing promise for diverse therapeutics like anticancer agents and insulin.
Advanced hybrid-stabilized cinacalcet nanocrystals for enhanced oral bioavailability: formulation and integrated in vitro/in vivo evaluations
Frontiers in Pharmacology · 2026 · Q1 · SJR 1.00 · FWCI 3.84 · 1 citations · Open access
Advanced hybrid-stabilized nanocrystals (HNCs) of cinacalcet (CINA), a poorly soluble drug, achieved a 10.36-fold increase in peak plasma concentration (Cmax) and a 7.76-fold increase in area under the curve (AUC) compared to a conventional suspension.
Enantioconvergent Assembly of Chiral Difluoromethyl Stereocenters by Nickel-Catalyzed Reductive Cross-Coupling
ACS Catalysis · 2026 · Q1 · SJR 3.00
A nickel-catalyzed method creates chiral difluoromethyl-containing molecules with high enantioselectivity using a novel difluoromethyl alkyl triflate reagent.
Diastereodivergent Morita–Baylis–Hillman Reaction of α,β-Unsaturated N-tert -Butanesulfinyl Imines and Trifluoromethyl Ketones
The Journal of Organic Chemistry · 2026 · Q2 · Open access
A new Morita–Baylis–Hillman reaction protocol achieves diastereodivergent synthesis of allylic γ-imino α-trifluoromethyl alcohol adducts, yielding two stereoisomers by tuning Lewis base and additives.
TsCl-Mediated, Copper-Catalyzed Deoxygenative Difluoromethoxylation Reaction of Quinoline- N -Oxides
The Journal of Organic Chemistry · 2026 · Q2
A new copper-catalyzed reaction uses TsCl and ethyl bromodifluoroacetate to synthesize 2-difluoromethoxy quinoline derivatives from quinoline-N-oxides in good to excellent yields.
Polarity-Matched Formal [1 + 4] Annulation of Fluoroalkyl Hydrazonoyl Halides with α-Halo Hydrazone-Derived Azoalkenes
Organic Letters · 2026 · Q1 · SJR 1.00
A new base-promoted reaction enables the formal [1 + 4] annulation of fluoroalkyl hydrazonoyl halides with α-halo acylhydrazone-derived azoalkenes, yielding CF2H- and CF3-substituted pyrazolines.
Dissolving Microneedles Loaded with Lipid Nanoparticles for Co-Delivery of siTNF-α and Dexamethasone as a Dual-Action Therapy for Psoriasis
ACS Applied Materials & Interfaces · 2026 · Q1 · SJR 1.00
A hyaluronic acid dissolving microneedle platform co-delivers siTNF-α and dexamethasone encapsulated within novel lipid nanoparticles (LNPs) for enhanced psoriasis treatment, significantly reducing disease severity in a mouse model.
Optimized Chitosan Nanoparticles for Enhanced Ciprofloxacin Delivery and Activity Against Resistant Bacteria
Pharmaceuticals · 2026 · Q1 · SJR 1.00
Optimized chitosan nanoparticles (NPs) loaded with ciprofloxacin (CIP) demonstrated a 2-4 fold reduction in minimum inhibitory and bactericidal concentrations against resistant strains of *Staphylococcus aureus* and *Pseudomonas aeruginosa*, compared to free CIP.
Low-Shrinkage 3D-Printed Polymeric Microneedle Arrays with Electroless Silver Coating for Enhanced Thermal and Mechanical Performance in Dermatological Applications
Materials · 2026 · Q2
A novel 3D-printed, silver-coated polymeric microneedle array offers enhanced thermal conductivity (37x increase) and mechanical strength for dermatological applications.
Mucoadhesive Nanoemulsions for Nose-to-Brain Delivery of Dimethyl Fumarate: Development, Characterization and Proof-of-Concept In Vivo Evaluation
Pharmaceutics · 2026 · Q1 · SJR 1.00
A novel mucoadhesive nanoemulsion (NE) formulation using geraniol and chitosan oleate delivered dimethyl fumarate (DMF) to the rat cerebrospinal fluid (CSF) with maximum concentrations of ~8 µg/mL for DMF and ~1.5 µg/mL for GER within 2 hours post-intranasal administration.
Recently added
Synthesis, Evaluation, and Context for Applications of SF5-Containing [1.1.1]Bicyclopentane and [ 2 ]Staffane “Hybrid Bioisosteres”
Journal of the American Chemical Society · 2026 · Q1 · SJR 5.00
Researchers developed scalable routes to SF5-substituted [1.1.1]bicyclopentanes (SF5-BCPs) and SF5-[2]staffanes (SF5-BCP-BCPs), demonstrating their utility as hybrid bioisosteres for tuning drug properties.
Advances in Cubosome-Based Transdermal Delivery: Structural Design, Manufacturing, and Engineering Strategies
ACS Omega · 2026 · Q1
Cubosomes, lipidic nanocarriers with bicontinuous cubic structures, show promise for transdermal drug delivery due to their high surface area and ability to encapsulate diverse compounds.
Magnetothermal Wax Capsule for Localized Gastrointestinal Drug Delivery
ACS Applied Bio Materials · 2026 · Q1
An ingestible capsule using superparamagnetic iron oxide nanoparticles (SPIONs) embedded in a wax matrix enables on-demand, site-specific drug release in the GI tract triggered by an external alternating magnetic field (AMF).
Development and stability evaluation of a low-complexity topical O/W emulsion containing CBD- and CBG-rich extracts
Journal of Cannabis Research · 2026 · Q1
A low-complexity O/W emulsion containing CBD- and CBG-rich extracts was developed, showing promising antioxidant and antimicrobial activities, but limited chemical stability, with CBD content decreasing by 65% over six months compared to 16% for CBG.
Natural Biodegradable Polymer-Based Microneedles for Controlled Drug Delivery: A Rational Design Framework and Translational Perspectives
Pharmaceutical Development and Technology · 2026 · Q2
A new rational design framework integrates therapeutic goals, polymer properties, mechanical performance, and release kinetics to optimize natural biodegradable polymer microneedles for drug delivery.
Polymer-based in-situ gelling nanoplatforms for buccal drug delivery: a comprehensive review of advances and challenges
International Journal of Polymeric Materials · 2026 · Q2
Polymer-based nanoplatforms that form gels in-situ show promise for buccal drug delivery, overcoming challenges of rapid clearance and oral movement by enhancing mucoadhesion and drug retention.
γ-Selective Deuteration of Unactivated C(sp3)–H Bonds of Aliphatic Amines via Pd Catalysis in D2O
Organic Letters · 2026 · Q1 · SJR 1.00
A new Pd-catalyzed method achieves selective deuteration at the γ-position of unactivated C(sp3)–H bonds in aliphatic amines using D2O as the deuterium source and 3-formyl-2-pyridone as a transient directing group.
Transforming Pediatric Dentistry with Chitosan Gel: Current Evidence and Emerging Trends—A Scoping Review
Materials · 2026 · Q2
Chitosan gel shows promise in pediatric dentistry, with evidence indicating antimicrobial and remineralizing effects in mouthwashes and varnishes, improved durability and antibacterial activity in dental materials, and enhanced outcomes in pulp therapy, though large trials are needed.
Journals in this field
The journals that publish most of this field’s papers. Quartile (Q1–Q4), SJR and h-index are from SCImago Journal Rank; “in this field” is how many of the journal’s pooled papers belong here. What is a Q1 journal? · What is the h-index?
| Journal | Quartile | SJR | h-index | In this field | Summaries |
|---|---|---|---|---|---|
| Pharmaceutics | Q1 | 1.00 | 157 | 3 | 10 |
| Journal of Organic Chemistry | Q2 | — | 256 | 3 | 12 |
| Chinese Journal of Chemistry | Q1 | 1.00 | 69 | 2 | 4 |
| Pharmaceuticals | Q1 | 1.00 | 120 | 2 | 3 |
| Organic Letters | Q1 | 1.00 | 268 | 2 | 11 |
| Frontiers in Pharmacology | Q1 | 1.00 | 203 | 2 | 10 |
| Materials | Q2 | — | 216 | 2 | 10 |
| Nature | Q1 | 19.00 | 1495 | 1 | 48 |
Every journal in Pharmaceutical Science (Q1–Q4) →
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