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Frontiers in Pharmacology· 2026Q1

Innovative dual-functional hybrid cationic PEGylated proniosomes as a smart nano-platform for Boosted vaginal delivery: multi-level in-vitro, ex-vivo, microbiological, and in-vivo studies

Sadek Ahmed, Osama Saher, Heba Attia, Abdurrahman M. Fahmy et al.

Short summary

A novel Dual-Functional Hybrid Cationic PEGylated Proniosomes (DHCPP) nano-platform significantly enhances vaginal delivery of Fenticonazole Nitrate (FTN), showing a 2.36-fold permeation increase and improved antifungal efficacy.

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Pharmaceutical SciencePharmacology, Toxicology and Pharmaceutics