Single-cell transcriptomic atlas of Alzheimer's disease middle temporal gyrus reveals region, cell type, and sex specificity of gene expression with novel genetic risk for MERTK in female

Short summary

Single-nucleus RNA sequencing of Alzheimer's disease (AD) middle temporal gyrus identified vulnerable RORB-negative/CDH9-expressing excitatory neurons and sex-independent reactive astrocytes, but sex-specific microglia. Combining transcriptomics with GWAS revealed MERTK genetic variation as a female-specific AD risk factor.

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