Key papers in Neurology
Pofolia’s corpus holds 40 papers from the Neurology subfield (2012–2025). The list below starts with the most cited.
Most cited
Ranked by citation count. Because citations accumulate over time, this list naturally leans towards work published a few years ago; for where the field is now, see “recently added”.
Copper-Zinc Superoxide Dismutase (SOD1) Is Released by Microglial Cells and Confers Neuroprotection against 6-OHDA Neurotoxicity
Neurosignals · 2012 · Q4 · FWCI 193.36 · 9,017 citations · Open access
Microglia release copper-zinc superoxide dismutase (SOD1), which protects neurons from 6-hydroxydopamine (6-OHDA) induced toxicity by increasing calcium influx.
Changes of Intestinal Functions in Liver Cirrhosis
Inflammatory Intestinal Diseases · 2016 · Q3 · FWCI 358.52 · 6,814 citations · Open access
Liver cirrhosis significantly alters intestinal functions, including dysmotility, prolonged transit times, and bacterial overgrowth (SIBO), which are linked to disease severity and complications like hepatic encephalopathy.
The Neurology of Eye Movements
Oxford University Press eBooks · 2015 · FWCI 102.70 · 3,805 citations
This new edition offers a modern synthesis of the neural basis for eye movements, integrating anatomical, physiological, and pharmacological data with current understanding of reflexive and voluntary gaze control.
Complement and microglia mediate early synapse loss in Alzheimer mouse models
Science · 2016 · Q1 · SJR 10.00 · FWCI 130.20 · 3,392 citations
In Alzheimer's disease models, complement protein C1q and microglia drive early synapse loss before plaque formation, a process previously thought to occur later and be driven by neuroinflammation.
The Blood–Brain Barrier
Cold Spring Harbor Perspectives in Biology · 2015 · Q1 · SJR 3.00 · 3,301 citations · Open access
The blood-brain barrier (BBB) is a unique system of blood vessels in the central nervous system that tightly regulates the passage of substances into the brain, crucial for neuronal function and protection.
<i>TREM2</i> Variants in Alzheimer's Disease
New England Journal of Medicine · 2012 · Q1 · SJR 18.00 · FWCI 93.49 · 3,090 citations · Open access
Rare heterozygous variants in the TREM2 gene significantly increase the risk of developing Alzheimer's disease, with a specific variant (R47H) showing a strong association.
Microglia Function in the Central Nervous System During Health and Neurodegeneration
Annual Review of Immunology · 2017 · Q1 · SJR 16.00 · FWCI 58.16 · 2,844 citations · Open access
Microglia, the brain's resident immune cells, are crucial for development, neuronal maintenance, and repair, but their altered function is implicated in neurodegeneration.
Non-invasive electrical and magnetic stimulation of the brain, spinal cord, roots and peripheral nerves: Basic principles and procedures for routine clinical and research application. An updated report from an I.F.C.N. Committee
Clinical Neurophysiology · 2015 · Q1 · SJR 1.00 · FWCI 95.93 · 2,786 citations
This report updates previous guidelines on non-invasive electrical and magnetic stimulation techniques for the brain, spinal cord, and nerves, reflecting advancements since 1994.
Variant of <i>TREM2</i> Associated with the Risk of Alzheimer's Disease
New England Journal of Medicine · 2012 · Q1 · SJR 18.00 · FWCI 84.52 · 2,629 citations
A rare mutation in the TREM2 gene (rs75932628-T, R47H substitution) significantly increases the risk of late-onset Alzheimer's disease by nearly threefold.
Neuroinflammation in neurodegenerative disorders: the roles of microglia and astrocytes
Translational Neurodegeneration · 2020 · Q1 · SJR 4.00 · FWCI 77.85 · 2,551 citations · Open access
This review highlights that microglia and astrocytes, key regulators of neuroinflammation in diseases like Alzheimer's and Parkinson's, exhibit complex and heterogeneous phenotypes beyond a simple neurotoxic vs. neuroprotective dichotomy.
Genomic Analysis of Reactive Astrogliosis
Journal of Neuroscience · 2012 · Q1 · SJR 1.00 · FWCI 47.04 · 2,476 citations · Open access
Reactive astrocytes, crucial for CNS injury response, exhibit distinct molecular phenotypes depending on the specific injury type, with at least 50% of gene expression changes being injury-specific.
Evidence-based guidelines on the therapeutic use of repetitive transcranial magnetic stimulation (rTMS): An update (2014–2018)
Clinical Neurophysiology · 2020 · Q1 · SJR 1.00 · FWCI 91.20 · 2,317 citations · Open access
Updated guidelines confirm definite efficacy (Level A) for high-frequency rTMS of the motor cortex for neuropathic pain and left prefrontal cortex for depression, and low-frequency rTMS of the motor cortex for stroke motor recovery.
Global, regional, and national burden of neurological disorders during 1990–2015: a systematic analysis for the Global Burden of Disease Study 2015
The Lancet Neurology · 2017 · Q1 · SJR 12.00 · FWCI 96.69 · 2,300 citations · Open access
Neurological disorders are the leading cause group of disability globally, accounting for 10.2% of all DALYs in 2015, and the second-leading cause of death. Despite falling age-standardized rates, the absolute number of deaths from these disorders rose 36.7% between 1990 and 2015.
Inflammation as a central mechanism in Alzheimer's disease
Alzheimer s & Dementia Translational Research & Clinical Interventions · 2018 · Q1 · SJR 1.00 · FWCI 60.23 · 2,269 citations · Open access
Inflammation, driven by sustained activation of brain immune cells like microglia, is now recognized as a third core pathology in Alzheimer's disease (AD), exacerbating amyloid and tau pathologies.
Blood-Brain Barrier: From Physiology to Disease and Back
Physiological Reviews · 2018 · Q1 · SJR 11.00 · FWCI 58.23 · 2,184 citations · Open access
This review synthesizes current understanding of the blood-brain barrier (BBB), detailing its physiological functions, mechanisms of breakdown in neurological diseases, and potential therapeutic applications.
Microglial <scp>M1/M2</scp> polarization and metabolic states
British Journal of Pharmacology · 2015 · Q1 · SJR 2.00 · FWCI 37.87 · 2,074 citations · Open access
This review explores how microglia, the brain's immune cells, shift between inflammatory (M1) and repair (M2) states, and how their energy metabolism, particularly mitochondrial activity, changes accordingly.
Microglia in Alzheimer’s disease
The Journal of Cell Biology · 2017 · Q1 · SJR 3.00 · FWCI 40.65 · 1,981 citations · Open access
Microglia, immune cells in the brain, play a dual role in Alzheimer's disease (AD), potentially offering protection while also contributing to neuronal damage and pathology.
How neuroinflammation contributes to neurodegeneration
Science · 2016 · Q1 · SJR 10.00 · FWCI 82.08 · 1,975 citations
Neuroinflammation, driven by changes in the brain's supportive glial cells and blood-brain barrier, is a key factor in the progression of neurodegenerative diseases like Alzheimer's and Parkinson's.
Mechanisms regulating intestinal barrier integrity and its pathological implications
Experimental & Molecular Medicine · 2018 · Q1 · SJR 5.00 · FWCI 37.82 · 1,922 citations · Open access
The intestinal epithelial cell layer, supported by tight junction proteins, acts as a crucial physical barrier against external factors. Imbalances in its regulation are linked to inflammatory bowel disease, obesity, and metabolic disorders.
New tools for studying microglia in the mouse and human CNS
Proceedings of the National Academy of Sciences · 2016 · Q1 · SJR 3.00 · FWCI 85.88 · 1,900 citations · Open access
Researchers have identified Transmembrane Protein 119 (Tmem119) as a highly specific marker for microglia in both mouse and human brains, enabling new tools for their study.
Recently added
A Meta-analysis of Repetitive Transcranial Magnetic Stimulation in the Treatment of Depression
Psychopharmacology Bulletin · 2025 · Q3 · 203 citations
Repetitive transcranial magnetic stimulation (rTMS) is statistically superior to sham stimulation for treating depression, demonstrating a moderate to large effect size (0.81). However, the clinical significance is modest, with only a small increase in response rates.
Microglia in neurodegenerative diseases: mechanism and potential therapeutic targets
Signal Transduction and Targeted Therapy · 2023 · Q1 · SJR 17.00 · FWCI 137.31 · 1,436 citations · Open access
Reactive microglia exhibit spatial and temporal heterogeneity, with some states correlating with disease hallmarks and specific functions, and can be both protective (phagocytosis) and detrimental (neuroinflammation).
The blood–brain barrier: Structure, regulation and drug delivery
Signal Transduction and Targeted Therapy · 2023 · Q1 · SJR 17.00 · FWCI 159.20 · 1,666 citations · Open access
The blood-brain barrier (BBB) impedes drug delivery to the central nervous system, but new materials science and nanotechnology offer strategies like transcytosis, intranasal administration, and ligand conjugation to enhance brain penetration for treating CNS disorders.
Neuroinflammation in neurodegenerative disorders: the roles of microglia and astrocytes
Translational Neurodegeneration · 2020 · Q1 · SJR 4.00 · FWCI 77.85 · 2,551 citations · Open access
This review highlights that microglia and astrocytes, key regulators of neuroinflammation in diseases like Alzheimer's and Parkinson's, exhibit complex and heterogeneous phenotypes beyond a simple neurotoxic vs. neuroprotective dichotomy.
A blood–brain barrier overview on structure, function, impairment, and biomarkers of integrity
Fluids and Barriers of the CNS · 2020 · Q1 · SJR 2.00 · FWCI 46.66 · 1,795 citations · Open access
This review details the blood-brain barrier's (BBB) structure, function, and the critical role of its integrity in maintaining brain homeostasis, alongside discussing BBB disruption in neurological conditions and biomarkers for assessing its permeability.
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