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PLoS ONE· 2026Q1

Methods for cost-efficient, whole genome sequencing surveillance for enhanced detection of outbreaks in a hospital setting

Kady Waggle, Marissa Pacey Griffith, Alecia B. Rokes, Vatsala Rangachar Srinivasa et al.

Short summary

A real-time whole genome sequencing (WGS) surveillance system, EDS-HAT, successfully identified hospital outbreaks missed by traditional methods and demonstrated cost savings, with per-sample costs under $100 in Phase 1 and under $70 in Phase 2.

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Clinical BiochemistryBiochemistry, Genetics and Molecular Biology