Clinical Biochemistry papers

Pofolia’s corpus holds 27 papers from Clinical Biochemistry (2026–2026), each with a short summary. Below, the 20 most-cited, then the most recently added.

At a glance

• Most cited: Methods for cost-efficient, whole genome sequencing surveillance for enhanced detection of outbreaks in a hospital setting (2026, 7 citations).
• The 20 papers listed have 7 citations between them.
• 14 of the 20 with a known journal quartile appeared in a Q1 journal.
• 4 have a free full text (open access).
• Most frequent journals: International Journal of Molecular Sciences, Alzheimer s Research & Therapy, American Journal of Medical Genetics Part A.
• Published between 2026 and 2026.

Most cited

Ranked by citation count. Because citations accumulate over time, this list naturally leans towards work published a few years ago; for where the field is now, see “recently added”. How to read the signals

• Methods for cost-efficient, whole genome sequencing surveillance for enhanced detection of outbreaks in a hospital setting

  PLoS ONE · 2026 · Q1 · FWCI 13.54 · 7 citations · Open access

  A real-time whole genome sequencing (WGS) surveillance system, EDS-HAT, successfully identified hospital outbreaks missed by traditional methods and demonstrated cost savings, with per-sample costs under $100 in Phase 1 and under $70 in Phase 2.

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• MALDI-TOF MS–based immunoassay using switching peptide for sensitive detection of intact foodborne bacteria

  Journal of Analytical Science & Technology · 2026 · Q2 · Open access

  A novel homogeneous immunoassay using MALDI-TOF MS and switching peptides enables sensitive, quantitative detection of five intact foodborne bacteria (E. coli O157:H7, S. typhimurium, L. monocytogenes, S. aureus, B. cereus) without washing steps.

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• The imperative of newborn screening programs in developing countries: beyond the illusion of health at birth

  Journal of Health Population and Nutrition · 2026 · Q1

  Newborn screening (NBS) is crucial for early detection of congenital disorders, yet LMICs lag significantly behind developed nations in implementation, creating health inequities.

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• Real-world clinical use of large neutral amino acids in phenylketonuria: a nationwide survey from Turkey under reimbursement constraints

  Orphanet Journal of Rare Diseases · 2026 · Q1 · SJR 1.00

  In Turkey, 95% of pediatric metabolic specialists use large neutral amino acids (LNAA) for phenylketonuria (PKU), primarily for dietary non-compliance and older patients, but reimbursement limits preferred treatment strategies.

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• Strain-resolved metabolomic chemotyping identifies tryptophan and γ-glutamyl peptides as MGO-AGEs breaking postbiotic compounds for carbonyl stress mitigation

  Gut Microbes · 2026 · Q1 · SJR 4.00 · Open access

  A novel strain-resolved metabolomic framework identified specific bacterial metabolite extracts, notably LFEAN031 enriched with tryptophan and γ-glutamyl peptides, that break methylglyoxal-advanced glycation end-products (MGO-AGEs) and mitigate carbonyl stress.

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• Continuous Renal Replacement Therapy for Acute Decompensation in Inborn Errors of Metabolism: Single-Center, Pediatric Cohort, 2014–2025

  Pediatric Critical Care Medicine · 2026 · Q1 · SJR 1.00

  Continuous renal replacement therapy (CRRT) significantly reduced ammonia (87.6%) and leucine (74.8%) levels in critically ill children with inborn errors of metabolism.

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• Dietary advanced glycation end products intake and osteoporosis risk in adults with type 2 diabetes mellitus

  Medicine · 2026 · Q2

  Higher dietary advanced glycation end product (AGEs) intake is associated with a 2.5-fold increased likelihood of osteoporosis in adults with type 2 diabetes (T2DM), independent of inflammatory markers and bone turnover markers.

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• Propionic Acidemia: An Ambispective Cohort Study on Phenotypic and Genotypic Characteristics at a Tertiary Center in Vietnam

  Genes · 2026 · Q2

  A study of 14 Vietnamese children with propionic acidemia (PA) found severe clinical outcomes, with 79% showing neurodevelopmental impairment and a 43% mortality rate, alongside common symptoms like acute encephalopathy and hyperammonemia.

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• Dried Blood Spot-Based Monitoring of Dietary Treatment in Children, Adolescents, and Young Adults with Inherited Disorders of Amino Acid Metabolism: A Four-Year Pilot Study

  Nutrients · 2026 · Q1 · SJR 1.00

  Home-collected dried blood spot (DBS) samples, analyzed via mass spectrometry, are a feasible method for monitoring dietary treatment in children and young adults with specific inherited amino acid metabolism disorders, showing utility particularly in maple syrup urine disease and glutaric aciduria type 1.

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• Role of the Gut–Liver–Kidney Axis in Disease Manifestation and Biomarker Alterations

  International Journal of Molecular Sciences · 2026 · Q1 · SJR 1.00

  The gut-liver-kidney axis significantly influences disease progression and the accumulation of endogenous and exogenous biomarkers, particularly in chronic disorders and neonatal inborn errors of metabolism.

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• HMGB1 Post-Translational Modifications in Epstein–Barr Virus-Associated Nasopharyngeal Carcinoma: Current Evidence, Emerging Mechanistic Concepts, and Unresolved Questions

  International Journal of Molecular Sciences · 2026 · Q1 · SJR 1.00

  Post-translational modifications (PTMs) like acetylation, phosphorylation, and lactylation influence High-mobility group box 1 (HMGB1) protein's role in Epstein-Barr virus (EBV)-associated nasopharyngeal carcinoma (NPC), potentially shifting it from a nuclear regulator to an extracellular immune mediator.

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• Mechanisms of Aging in Phenylketonuria ( PKU )

  American Journal of Medical Genetics Part A · 2026 · Q2

  Adults with PKU show signs of accelerated aging, including cardiovascular issues, obesity, diabetes, hypertension, lower bone density, white matter changes, and cognitive deficits, despite early treatment.

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• Construction of a self-amplifying mRNA-LNP complex for phenylalanine hydroxylase and its efficacy evaluation in gene therapy for phenylketonuria

  iScience · 2026 · Q1 · SJR 1.00

  A self-amplifying mRNA (saRNA) delivered via lipid nanoparticles (LNPs) achieved sustained phenylalanine hydroxylase (PAH) activity for 14 days in mice with phenylketonuria (PKU), requiring one-sixth the dose of conventional mRNA and showing no toxicity.

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• RAGE signaling in acute myocardial infarction: sRAGE as a dynamic biomarker and emerging therapeutic target

  Frontiers in Endocrinology · 2026 · Q1 · SJR 1.00 · Open access

  Soluble RAGE (sRAGE) levels, a marker of RAGE pathway activity, are inconsistently associated with acute myocardial infarction (AMI) severity, but their dynamic changes over time may offer distinct prognostic information.

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• Early Prediction of Carbapenem Resistance in Gram-Negative Organisms at Culture Ordering from Routinely Collected Hospital Data: Temporal and External Validation of ORDER-CARB

  Infectious Diseases and Therapy · 2026 · Q1 · SJR 1.00

  The ORDER-CARB model predicts the probability of carbapenem-resistant Gram-negative organisms at the time of culture ordering, achieving an AUROC of 0.858 in internal testing and 0.797-0.876 in external validation across different hospital cohorts.

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• Clearance of amino acids, trace elements, and carnitine during CRRT: the carnitine dichotomy

  BMC Nephrology · 2026 · Q1

  Continuous renal replacement therapy (CRRT) significantly depleted free carnitine and short-chain acylcarnitines (SCACs) by 24 hours in critically ill patients (n=23), with SCAC depletion strongly correlating with dialytic clearance, while long-chain acylcarnitines showed zero clearance.

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• Targeted degradation of RAGE restores microglial homeostasis and rescues cognitive deficits in 3xTg-AD mice

  Alzheimer s Research & Therapy · 2026 · Q1 · SJR 2.00

  A novel PROTAC compound (18a) effectively degrades the Receptor for Advanced Glycation End-products (RAGE) in 3xTg-AD mice, restoring microglial homeostasis and improving cognitive function.

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• Rapid Antimicrobial Susceptibility Testing Using Direct Centrifugation Significantly Reduces Turnaround Time While Maintaining High Diagnostic Accuracy in Bloodstream Infections

  Diagnostics · 2026 · Q2

  A direct centrifugation method for antimicrobial susceptibility testing (AST) cut the average turnaround time from 48.74 to 25.13 hours, a reduction of over 23 hours, while maintaining high diagnostic accuracy, especially for Gram-negative bacteria.

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• Comprehensive review of antimicrobial susceptibility testing from traditional methods to emerging technologies

  Discover Applied Sciences · 2026 · Q2

  This review highlights the principles, merits, demerits, and clinical applications of both classical and modern antimicrobial susceptibility testing (AST) techniques, emphasizing the advancements in rapid identification and detection of resistance markers.

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• CRISPR/dCas9-induced upregulation of endogenous apolipoprotein A1 and paraoxonase 1 genes reduces the aortic lipid deposits in apoE−/− mice

  Molecular Biomedicine · 2026 · Q1 · SJR 2.00

  CRISPR/dCas9 technology successfully upregulated endogenous apolipoprotein A1 (APOA1) and paraoxonase 1 (PON1) genes in mice, leading to a 50% reduction in aortic lipid deposits.

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Recently added

• Dietary intake, metabolic control and growth in patients with organic acidemia and urea cycle disorders

  BMC Pediatrics · 2026 · Q1

  Growth impairment is highly prevalent in patients with organic acidemias (OA) and urea cycle disorders (UCD), with stunting and underweight common across groups, despite adequate total protein intake and adherence to disease-specific guidelines.

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• Fermented soy protein Maillard reaction products attenuate Gardnerella vaginalis-induced vaginal and intestinal inflammation: involvement of TLR2/NF-κB suppression and short-chain fatty acid restoration

  Journal of Functional Foods · 2026 · Q1

  Fermented soy protein Maillard reaction products (MRPF) significantly reduced Gardnerella vaginalis-induced inflammation in mice, restoring gut barrier function and short-chain fatty acid (SCFA) levels.

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• Optimization of culture read times using full microbiology laboratory automation

  Journal of Clinical Microbiology · 2026 · Q1 · SJR 1.00

  Microbiology laboratory automation (MLA) enables earlier culture reads, with non-urine specimens ready for workup by 16h (50%) and 24h (92%), and urine cultures by 16h (90%), without compromising identification or antimicrobial susceptibility testing (AST) accuracy.

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• Insulin enhances RAGE ectodomain shedding by inducing Rab14-dependent ADAM10 cell surface trafficking in human aortic endothelial cells

  PLoS ONE · 2026 · Q1

  Insulin promotes the shedding of the receptor for advanced glycation end products (RAGE) by activating AKT, which drives Rab14-dependent transport of the enzyme ADAM10 to the cell surface in human aortic endothelial cells.

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• In vitro antiglycation, antioxidant and anti-inflammatory activities of Launaea taraxacifolia: inhibition of pentosidine- and vesperlysine-like advanced glycation end-products

  Scientific Reports · 2026 · Q1

  A 70% ethanolic extract of Launaea taraxacifolia (LTE) significantly inhibited the formation of advanced glycation end-products (AGEs) in vitro, with strongest activity against fructose-induced pentosidine-like AGEs (IC50 = 0.323 mg/mL).

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• Anaerobic bacteria: a neglected reservoir of mobile oxazolidinone resistance genes

  Gut Microbes · 2026 · Q1 · SJR 4.00

  Anaerobic gut bacteria harbor mobile oxazolidinone resistance genes (MORGs), including the first report of cfr(B) in Gram-negative bacteria and optrA in new hosts, suggesting they are a critical, overlooked reservoir for these last-resort antibiotic resistance genes.

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• Early Prediction of Carbapenem Resistance in Gram-Negative Organisms at Culture Ordering from Routinely Collected Hospital Data: Temporal and External Validation of ORDER-CARB

  Infectious Diseases and Therapy · 2026 · Q1 · SJR 1.00

  The ORDER-CARB model predicts the probability of carbapenem-resistant Gram-negative organisms at the time of culture ordering, achieving an AUROC of 0.858 in internal testing and 0.797-0.876 in external validation across different hospital cohorts.

  Go to source →

• Clearance of amino acids, trace elements, and carnitine during CRRT: the carnitine dichotomy

  BMC Nephrology · 2026 · Q1

  Continuous renal replacement therapy (CRRT) significantly depleted free carnitine and short-chain acylcarnitines (SCACs) by 24 hours in critically ill patients (n=23), with SCAC depletion strongly correlating with dialytic clearance, while long-chain acylcarnitines showed zero clearance.

  Go to source →

Journals in this field

The journals that publish most of this field’s papers. Quartile (Q1–Q4), SJR and h-index are from SCImago Journal Rank; “in this field” is how many of the journal’s pooled papers belong here. What is a Q1 journal? · What is the h-index?

Every journal in Clinical Biochemistry (Q1–Q4) →

Other subfields in Biochemistry, Genetics and Molecular Biology

• Biochemistry (Biochemistry, Genetics and Molecular Biology)
• Genetics (Biochemistry, Genetics and Molecular Biology)
• Cell Biology
• Molecular Biology

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