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PLoS Computational Biology· 2026Q1

Hunting for microsatellite instability in long-read data with Owl

Zev Kronenberg, Byunggil Yoo, Khi Pin Chua, Mark J. P. Chaisson et al.

Short summary

Owl, a new bioinformatic tool, quantifies microsatellite instability (MSI) from long-read genomic data, identifying MSI in 6 cancer cell lines and one astrocytoma tumor with 10-27% unstable markers.

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Field: Pathology and Forensic Medicine

Pathology and Forensic MedicineMedicine