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Journal of Medicinal Chemistry· 2026Q1

Discovery of DT-9081, a Potent and Orally Bioavailable Small Molecule Antagonist of the EP4 Receptor for the Treatment of Solid Cancers

Anne‐Laure Blayo, Gaël Hommet, Mickaël Fer, Célia Halter et al.

Short summary

DT-9081, a novel small molecule EP4 receptor antagonist, shows potent antagonism and favorable preclinical safety, making it a promising oral treatment candidate for solid cancers.

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Field: Pharmacology

PharmacologyMedicine