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Nature· 2026Q1

Integrated signatures define mutational processes in prostate cancer

Andreas J. Gruber, André Vidas Olsen, Bárbara Hernando, Kevin C. L. Cheng et al.

Short summary

Eight integrated mutational footprints (IMFs) explain 85% of mutational processes in 959 prostate cancer genomes, driven by androgen receptor-mediated mutagenesis and replication stress.

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Field: Pulmonary and Respiratory Medicine

Pulmonary and Respiratory MedicineMedicine