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Biology of Sex Differences· 2026Q1

Sex-specific hippocampal trajectories induced by peripubertal and adult acute stress: proteomic profile, microglial alterations, neurogenic dysregulation, and depression-like behaviors

P. Chaves-Peña, J. Munoz-Martin, M. I. Infantes-López, E. Zambrana-Infantes et al.

Short summary

Acute stress during adolescence and adulthood induces distinct sex-specific molecular and cellular changes in the hippocampus, affecting neurogenesis and microglial activity, with broader proteomic alterations seen in females, particularly after combined stress.

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Field: Behavioral Neuroscience

Behavioral NeuroscienceNeuroscience