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Immuno· 2026Q2· Review

Cellular Senescence in Oral Lichen Planus: Evidence, Limitations, and Future Perspectives

Domenico De Falco, Alberta Lucchese, Giuseppe Pannone, Massimo Petruzzi

Short summary

Cellular senescence, particularly in PDGFRα-positive mesenchymal cells, is linked to oral lichen planus (OLP) by enhanced CXCL12–CXCR4 and CD44 signaling that activates T cells and injures keratinocytes.

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PeriodonticsDentistry