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Journal of Proteome Research· 2026Q1

Integrated Proteomic Profiling of Inner Ear and Systemic Fluids Following Noise-Induced Hearing Loss in Rats

Motahare Khorrami, Zeshan Ali, Robert D. Gay, Ya Lang Enke et al.

Short summary

A proteomic analysis of rat inner ear fluids (perilymph, CSF) and systemic fluids (blood, plasma) identified 50-281 differentially expressed proteins following noise-induced hearing loss (NIHL), revealing a shared inflammatory response (e.g., IGHM upregulation) and distinct local (metabolic, injury) vs. systemic (lipid-regulatory) pathway involvement.

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Field: Sensory Systems

Sensory SystemsNeuroscience