Key papers in Sensory Systems
Pofolia’s corpus holds 64 papers from the Sensory Systems subfield (2012–2023). The list below starts with the most cited.
Most cited
Ranked by citation count. Because citations accumulate over time, this list naturally leans towards work published a few years ago; for where the field is now, see “recently added”.
SARS-CoV-2 is associated with changes in brain structure in UK Biobank
Nature · 2022 · Q1 · SJR 19.00 · FWCI 170.15 · 1,557 citations · Open access
COVID-19 infection, even in non-hospitalized cases, is linked to measurable changes in brain structure and cognitive decline.
Olfactory transmucosal SARS-CoV-2 invasion as a port of central nervous system entry in individuals with COVID-19
Nature Neuroscience · 2020 · Q1 · SJR 11.00 · FWCI 83.71 · 1,501 citations · Open access
SARS-CoV-2 can enter the central nervous system (CNS) by crossing the olfactory mucosa, exploiting the proximity of neural and mucosal tissues. The virus was detected in both the nasopharynx and brain, with evidence of neurotropism and associated CNS damage.
Non-neuronal expression of SARS-CoV-2 entry genes in the olfactory system suggests mechanisms underlying COVID-19-associated anosmia
Science Advances · 2020 · Q1 · SJR 4.00 · FWCI 76.38 · 1,247 citations · Open access
SARS-CoV-2 entry genes ACE2 and TMPRSS2 are expressed in non-neuronal support cells within the olfactory system, not directly in sensory neurons.
Store-Operated Calcium Channels
Physiological Reviews · 2015 · Q1 · SJR 11.00 · FWCI 44.86 · 1,240 citations
Store-operated calcium channels (SOCs), crucial for cellular functions, are activated by endoplasmic reticulum (ER) calcium depletion, with STIM proteins sensing depletion and Orai proteins forming the channels at ER-plasma membrane junctions.
Olfactory receptor responding to gut microbiota-derived signals plays a role in renin secretion and blood pressure regulation
Proceedings of the National Academy of Sciences · 2013 · Q1 · SJR 3.00 · FWCI 22.67 · 1,175 citations · Open access
A kidney-expressed olfactory receptor, Olfr78, responds to gut microbiota-derived short-chain fatty acids (SCFAs) and mediates renin secretion, influencing blood pressure regulation in mice.
TRP Channels and Pain
Annual Review of Cell and Developmental Biology · 2013 · Q1 · SJR 7.00 · FWCI 34.37 · 1,135 citations
Natural irritants from plants like pepper and mint have identified three Transient Receptor Potential (TRP) ion channels (TRPV1, TRPM8, TRPA1) as key molecular detectors of thermal and chemical stimuli that initiate pain sensation.
Essential oils used in aromatherapy: A systemic review
Asian Pacific Journal of Tropical Biomedicine · 2015 · Q3 · FWCI 20.35 · 1,113 citations
This systematic review compiles existing literature on the therapeutic, medical, cosmetic, and psychological uses of essential oils in aromatherapy.
Genome sequence of the hot pepper provides insights into the evolution of pungency in Capsicum species
Nature Genetics · 2014 · Q1 · SJR 15.00 · FWCI 34.46 · 1,075 citations · Open access
Researchers have sequenced the genome of the hot pepper (Capsicum annuum), revealing it is four times larger than its relative, the tomato. This genomic data offers insights into the evolution of pepper's spiciness and other traits.
Olfactory Disorders and Quality of Life--An Updated Review
Chemical Senses · 2014 · Q3 · FWCI 18.29 · 933 citations
Loss of the sense of smell, common in about one-fifth of the population, significantly impacts daily life by disrupting food enjoyment, hazard detection, and social interactions.
Humans Can Discriminate More than 1 Trillion Olfactory Stimuli
Science · 2014 · Q1 · SJR 10.00 · FWCI 32.95 · 924 citations
Humans can discriminate at least 1 trillion different olfactory stimuli, vastly exceeding previous estimates and surpassing the discriminatory capacity of human vision and hearing.
Smell dysfunction: a biomarker for COVID‐19
International Forum of Allergy & Rhinology · 2020 · Q1 · SJR 1.00 · FWCI 57.54 · 841 citations · Open access
Quantitative smell testing revealed that 98% of COVID-19 patients exhibited smell dysfunction, with an average score of 20.98 compared to 34.10 in controls.
Age-Related Cochlear Synaptopathy: An Early-Onset Contributor to Auditory Functional Decline
Journal of Neuroscience · 2013 · Q1 · SJR 1.00 · FWCI 17.41 · 834 citations · Open access
Age-related hearing loss is linked to early-onset degeneration of cochlear synapses and nerve fibers, occurring even before changes in hearing thresholds or hair cell counts.
Noise-induced cochlear neuropathy is selective for fibers with low spontaneous rates
Journal of Neurophysiology · 2013 · Q2 · 792 citations
Noise exposure can damage auditory nerve fibers without affecting hearing thresholds, a paradox explained by the selective loss of fibers with low and medium spontaneous rates, which are crucial for hearing in noisy environments.
Association of chemosensory dysfunction and COVID‐19 in patients presenting with influenza‐like symptoms
International Forum of Allergy & Rhinology · 2020 · Q1 · SJR 1.00 · FWCI 55.95 · 788 citations · Open access
Loss of smell (anosmia) and taste (ageusia) were strongly associated with COVID-19 positivity in patients with flu-like symptoms, with adjusted odds ratios of 10.9 and 10.2 respectively.
Clinical Practice Guideline: Tinnitus
Otolaryngology · 2014 · FWCI 19.07 · 757 citations
New clinical guidelines strongly recommend distinguishing bothersome tinnitus from non-bothersome cases and advise against routine head and neck imaging for most tinnitus patients.
Alterations in Smell or Taste in Mildly Symptomatic Outpatients With SARS-CoV-2 Infection
JAMA · 2020 · Q1 · SJR 5.00 · FWCI 51.66 · 743 citations · Open access
This study evaluated the prevalence, intensity, and timing of altered smell or taste in outpatients with mild SARS-CoV-2 symptoms.
Cochlear synaptopathy in acquired sensorineural hearing loss: Manifestations and mechanisms
Hearing Research · 2017 · Q2 · FWCI 34.36 · 724 citations
A review highlights cochlear synaptopathy, a permanent disruption of communication between inner hair cells and cochlear nerve fibers, which can occur before traditional hearing loss is detectable.
Position paper on olfactory dysfunction
Rhinology Journal · 2017 · Q1 · SJR 2.00 · FWCI 29.09 · 718 citations · Open access
This position paper proposes standardized methodologies for assessing olfactory dysfunction to improve research quality and treatment development, addressing the current heterogeneity in definitions and assessment techniques.
A systematic review of the reporting of tinnitus prevalence and severity
Hearing Research · 2016 · Q2 · FWCI 8.05 · 716 citations
A systematic review of 40 studies found widespread inconsistency in how tinnitus is defined and reported, leading to prevalence estimates varying from 5.1% to 42.7%. Even when using the same definition, prevalence estimates ranged from 11.9% to 30.3%.
Rats and Humans Can Optimally Accumulate Evidence for Decision-Making
Science · 2013 · Q1 · SJR 10.00 · FWCI 20.04 · 706 citations
Researchers found that the internal memory used to accumulate evidence during decision-making is noiseless in both rats and humans, with variability solely originating from incoming sensory information.
Recently added
TRP (transient receptor potential) ion channel family: structures, biological functions and therapeutic interventions for diseases
Signal Transduction and Targeted Therapy · 2023 · Q1 · SJR 17.00 · FWCI 79.81 · 487 citations · Open access
This review details the 28 mammalian TRP ion channel proteins, organized into seven subfamilies, which act as sensors for diverse signals and are permeable to various cations, playing roles in heat, cold, pain, vision, and taste.
Global Prevalence and Incidence of Tinnitus
JAMA Neurology · 2022 · Q1 · SJR 5.00 · FWCI 47.14 · 510 citations · Open access
Tinnitus affects 14.4% of adults globally, with prevalence increasing with age, according to a meta-analysis of 113 studies.
SARS-CoV-2 is associated with changes in brain structure in UK Biobank
Nature · 2022 · Q1 · SJR 19.00 · FWCI 170.15 · 1,557 citations · Open access
COVID-19 infection, even in non-hospitalized cases, is linked to measurable changes in brain structure and cognitive decline.
Spatial transcriptomics of dorsal root ganglia identifies molecular signatures of human nociceptors
Science Translational Medicine · 2022 · Q1 · SJR 7.00 · FWCI 45.97 · 460 citations · Open access
Spatial transcriptomics of human dorsal root ganglia (DRG) identified 5 distinct C nociceptor subtypes, revealing molecular signatures and potential drug targets, with notable sex differences in calcitonin gene expression.
COVID-19–related anosmia is associated with viral persistence and inflammation in human olfactory epithelium and brain infection in hamsters
Science Translational Medicine · 2021 · Q1 · SJR 7.00 · FWCI 50.64 · 503 citations
SARS-CoV-2 infection persists in the olfactory neuroepithelium, causing inflammation and anosmia in patients and hamsters.
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