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ACS Sustainable Chemistry & Engineering· 2026Q1

MPNN-Guided Redesign of PET Hydrolases with Enhanced Catalytic Activity below the PET Glass Transition Temperature

Aransa Griñén, Valeria Eltit-Villarroel, Francisca Durán-Osorio, Javiera Avilés et al.

Short summary

Redesigned PET hydrolase variants (D5, D11) show enhanced depolymerization activity at 50°C, matching wild-type PHL7's efficiency at 70°C, with improved protein expression and thermostability.

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BiomaterialsMaterials Science