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Pharmacological Research· 2026Q1· Review

GPR75: A dual-ligand receptor for 20-HETE and CCL5 with emerging roles in central and peripheral regulation of metabolic diseases

Yupeng Hou, Shu-Jing Liu, Liangming Li

Short summary

G protein-coupled receptor 75 (GPR75) is a newly identified regulator of metabolic processes, with loss-of-function variants linked to reduced risk of obesity, type 2 diabetes, MASLD, and hypertension.

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BiochemistryBiochemistry, Genetics and Molecular Biology