Angewandte Chemie International Edition· 2012Q1
On the Interpretation of Deuterium Kinetic Isotope Effects in CH Bond Functionalizations by Transition‐Metal Complexes
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- Q1SCImago
- 2012year
Short summary
A primary deuterium kinetic isotope effect (KIE) in CH bond functionalization does not always indicate C-H bond cleavage in the rate-determining step.
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Key points
- Kinetic isotope effects (KIEs) can offer insights into reaction mechanisms.
- Primary KIEs arise from H/D substitution.
- A primary KIE does not guarantee C-H bond cleavage in the rate-determining step.
- Careful experimental design and interpretation are crucial for KIE studies.
AI-generated from the title and abstract; the full text is not read.
Abstract
Rate versus selectivity determining: The measurement of a kinetic isotope effect (KIE) can provide valuable information about the mechanism of a reaction, but care must be taken in the design and interpretation of KIE experiments. Depending on the experiment that is conducted, the observation of a primary KIE resulting from H/D substitution does not necessarily imply that CH bond cleavage occurs during the rate-determining step of a reaction. FG=functional group.
The authors' abstract, as published at the source. Angewandte Chemie International Edition, 2012 · DOI ↗
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Field: Inorganic Chemistry
Inorganic ChemistryChemistry