Journal of the American Chemical Society· 2015Q1
One-pot Synthesis of Metal–Organic Frameworks with Encapsulated Target Molecules and Their Applications for Controlled Drug Delivery
- 1,372citations
- Q1SCImago
- 2015year
Short summary
Researchers developed a one-pot method to synthesize Metal-Organic Frameworks (MOFs) that encapsulate large drug molecules like doxorubicin (DOX) within zeolitic imidazolate framework (ZIF-8) crystals.
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Key points
- Developed a one-pot synthesis for MOFs that simultaneously encapsulates target molecules.
- Successfully encapsulated large molecules like doxorubicin (DOX) within ZIF-8 crystals.
- Achieved homogeneous drug distribution and tunable loading within the MOF crystals.
- DOX-loaded ZIF-8 crystals showed higher efficacy against breast cancer cell lines than free DOX.
- Demonstrated pH-responsive drug release for cancer therapy.
AI-generated from the title and abstract; the full text is not read.
Abstract
Many medical and chemical applications require target molecules to be delivered in a controlled manner at precise locations. Metal-organic frameworks (MOFs) have high porosity, large surface area, and tunable functionality and are promising carriers for such purposes. Current approaches for incorporating target molecules are based on multistep postfunctionalization. Here, we report a novel approach that combines MOF synthesis and molecule encapsulation in a one-pot process. We demonstrate that large drug and dye molecules can be encapsulated in zeolitic imidazolate framework (ZIF) crystals. The molecules are homogeneously distributed within the crystals, and their loadings can be tuned. We show that ZIF-8 crystals loaded with the anticancer drug doxorubicin (DOX) are efficient drug delivery vehicles in cancer therapy using pH-responsive release. Their efficacy on breast cancer cell lines is higher than that of free DOX. Our one-pot process opens new possibilities to construct multifunctional delivery systems for a wide range of applications.
The authors' abstract, as published at the source. Journal of the American Chemical Society, 2015 · DOI ↗
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Field: Inorganic Chemistry
Inorganic ChemistryChemistry