Angewandte Chemie International Edition· 2018Q1· Review
Electrifying Organic Synthesis
- 1,511citations
- Q1SCImago
- 2018year
Short summary
Electrochemical synthesis offers a greener, safer, and more efficient alternative to traditional organic synthesis, enabling fewer steps, milder conditions, and novel reaction pathways.
AI-generated from the title and abstract; the full text is not read.
Key points
- Electrochemical synthesis uses electrons as reagents, eliminating reagent waste.
- It enables reagent regeneration for electrocatalytic transformations.
- Processes are inherently safer, require fewer steps, and use milder conditions.
- Renewable electricity can be used as a terminal oxidizing or reducing agent for ultra-sustainability.
AI-generated from the title and abstract; the full text is not read.
Abstract
The direct synthetic organic use of electricity is currently experiencing a renaissance. More synthetically oriented laboratories working in this area are exploiting both novel and more traditional concepts, paving the way to broader applications of this niche technology. As only electrons serve as reagents, the generation of reagent waste is efficiently avoided. Moreover, stoichiometric reagents can be regenerated and allow a transformation to be conducted in an electrocatalytic fashion. However, the application of electroorganic transformations is more than minimizing the waste footprint, it rather gives rise to inherently safe processes, reduces the number of steps of many syntheses, allows for milder reaction conditions, provides alternative means to access desired structural entities, and creates intellectual property (IP) space. When the electricity originates from renewable resources, this surplus might be directly employed as a terminal oxidizing or reducing agent, providing an ultra-sustainable and therefore highly attractive technique. This Review surveys recent developments in electrochemical synthesis that will influence the future of this area.
The authors' abstract, as published at the source. Angewandte Chemie International Edition, 2018 · DOI ↗
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Field: Organic Chemistry
Organic ChemistryChemistry