Chemical Reviews· 2017Q1· Review
Chalcone: A Privileged Structure in Medicinal Chemistry
- 1,422citations
- Q1SCImago
- 2017year
Short summary
Chalcones, readily synthesized natural and synthetic compounds, are highlighted as a privileged scaffold in medicinal chemistry due to their broad range of biological activities and clinical potential against various diseases.
AI-generated from the title and abstract; the full text is not read.
Key points
- Chalcones are a common, easily synthesized scaffold found in nature.
- Chalcone derivatives display numerous biological activities.
- These compounds show potential for clinical applications against various diseases.
- Research covers isolation, synthesis, biological properties, and mechanisms of action.
AI-generated from the title and abstract; the full text is not read.
Abstract
Privileged structures have been widely used as an effective template in medicinal chemistry for drug discovery. Chalcone is a common simple scaffold found in many naturally occurring compounds. Many chalcone derivatives have also been prepared due to their convenient synthesis. These natural products and synthetic compounds have shown numerous interesting biological activities with clinical potentials against various diseases. This review aims to highlight the recent evidence of chalcone as a privileged scaffold in medicinal chemistry. Multiple aspects of chalcone will be summarized herein, including the isolation of novel chalcone derivatives, the development of new synthetic methodologies, the evaluation of their biological properties, and the exploration of the mechanisms of action as well as target identification. This review is expected to be a comprehensive, authoritative, and critical review of the chalcone template to the chemistry community.
The authors' abstract, as published at the source. Chemical Reviews, 2017 · DOI ↗
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Field: Organic Chemistry
Organic ChemistryChemistry