Chemical Society Reviews· 2014Q1· Review
Cucurbiturils: from synthesis to high-affinity binding and catalysis
- 1,348citations
- Q1SCImago
- 2014year
Short summary
Cucurbiturils (CBn) are a young family of molecular containers that form stable complexes with diverse guests, including drugs, amino acids, and even proteins, exhibiting record binding affinities and finding applications in sensing and drug delivery.
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Key points
- Cucurbiturils (CBn) are molecular containers with a young but rapidly growing field of study.
- They form stable complexes with a diverse range of guests, including drugs, amino acids, saccharides, hydrocarbons, and proteins.
- CBn exhibit record binding affinities for guest molecules within their hydrophobic cavity.
- Applications span sensing, drug delivery, and catalysis, with ongoing research in synthesis of new homologues and derivatives.
AI-generated from the title and abstract; the full text is not read.
Abstract
In the wide area of supramolecular chemistry, cucurbit[n]urils (CBn) present themselves as a young family of molecular containers, able to form stable complexes with various guests, including drug molecules, amino acids and peptides, saccharides, dyes, hydrocarbons, perfluorinated hydrocarbons, and even high molecular weight guests such as proteins (e.g., human insulin). Since the discovery of the first CBn, CB6, the field has seen tremendous growth with respect to the synthesis of new homologues and derivatives, the discovery of record binding affinities of guest molecules in their hydrophobic cavity, and associated applications ranging from sensing to drug delivery. In this review, we discuss in detail the fundamental properties of CBn homologues and their cyclic derivatives with a focus on their synthesis and their applications in catalysis.
The authors' abstract, as published at the source. Chemical Society Reviews, 2014 · DOI ↗
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Field: Organic Chemistry
Organic ChemistryChemistry