Chemical Society Reviews· 2013Q1· Review
Recent progress in the development of near-infrared fluorescent probes for bioimaging applications
- 1,791citations
- Q1SCImago
- 2013year
Short summary
Researchers highlight advances in near-infrared (NIR) fluorescent probes for bioimaging, noting their deep tissue penetration, reduced photo-damage, and low background fluorescence.
AI-generated from the title and abstract; the full text is not read.
Key points
- NIR fluorescent probes offer advantages for bioimaging, including deep photon penetration and reduced photo-damage.
- Low background auto-fluorescence from biomolecules enhances signal detection.
- Recent research has significantly increased the number of analyte-responsive NIR probes.
- Probes are being developed to detect a variety of biological species like ROS/RNS, metal ions, anions, and enzymes, as well as intracellular pH.
AI-generated from the title and abstract; the full text is not read.
Abstract
Near-infrared (NIR) fluorescent dyes have emerged as promising modalities for monitoring the levels of various biologically relevant species in cells and organisms. The use of NIR probes enables deep photon penetration in tissue, minimizes photo-damage to biological samples, and produces low background auto-fluorescence from biomolecules present in living systems. The number of new analyte-responsive NIR fluorescent probes has increased substantially in recent years as a consequence of intense research efforts. In this tutorial review, we highlight recent advances (2010-2013) made in the development and applications of NIR fluorescent probes. The review focuses on NIR fluorescent probes that have been devised to sense various biologically important species, including ROS/RNS, metal ions, anions, enzymes and other related species, as well as intracellular pH changes. The basic principles involved in the design of functional NIR fluorescent probes and suggestions about how to expand applications of NIR imaging agents are also described.
The authors' abstract, as published at the source. Chemical Society Reviews, 2013 · DOI ↗
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Field: Spectroscopy
SpectroscopyChemistry