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Analytical Chemistry· 2014Q1

MultiNotch MS3 Enables Accurate, Sensitive, and Multiplexed Detection of Differential Expression across Cancer Cell Line Proteomes

Graeme C. McAlister, David P. Nusinow, Mark P. Jedrychowski, Martin Wühr et al.

Short summary

A new method, MultiNotch MS3, significantly enhances the accuracy and sensitivity of quantitative proteomics by increasing reporter ion signals 10-fold, enabling the precise measurement of differential protein expression across cancer cell lines.

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Field: Spectroscopy

SpectroscopyChemistry