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Netherlands Heart Journal· 2026Q2

Effects on atrial fibrillation symptom burden of an obesity-focused cardiac rehabilitation program: Insights from the OPTICARE XL trial

N Tenbult - Van Limpt, Richard A. J. Post, Nienke ter Hoeve, Iris den Uijl et al.

Short summary

An obesity-focused cardiac rehabilitation program significantly reduced atrial fibrillation (AF) symptom burden in patients with non-valvular AF, according to the OPTICARE XL trial.

AI-generated from the title and abstract; the full text is not read.

Key points

  • Obesity is a major modifiable risk factor for atrial fibrillation (AF).
  • Weight loss and regular exercise are crucial for AF management.
  • Comprehensive programs targeting weight loss, physical activity, and behavioral change can reduce AF recurrence and symptom burden.
  • Cardiac rehabilitation (CR) offers a framework for these lifestyle modifications.
  • The effectiveness of CR, particularly when tailored for obese patients, in reducing AF symptom burden was uncertain prior to this trial.

AI-generated from the title and abstract; the full text is not read.

Abstract

Obesity is a major modifiable risk factor for atrial fibrillation (AF) [ 1 ]. Sustained weight loss and regular exercise are therefore key components of AF management [ 2 ]. In symptomatic AF populations, comprehensive risk factor management programmes targeting weight loss, physical activity, and behavioural change have been associated with reduced AF recurrence and symptom burden [ 1 , 3 , 4 ]. Cardiac rehabilitation (CR) provides a scalable framework for lifestyle modification, risk factor management (including weight loss), and improvement of exercise capacity and quality of life [ 5 ]. Whether CR, particularly when tailored for patients with obesity, is effective to reduce AF symptom burden remains uncertain [ 6 ]. We therefore evaluated the effect of an obesity-focused CR programme on AF symptom burden in patients with non-valvular AF [ 7 ].

The authors' abstract, as published at the source. Netherlands Heart Journal, 2026 · DOI ↗

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Field: Cardiology and Cardiovascular Medicine

Cardiology and Cardiovascular MedicineMedicine