Anaesthesia· 2026Q1
Remimazolam and emergence delirium
- 1citations
- Q1SCImago
- 2026year
Short summary
Remimazolam did not meet noninferiority to propofol in preventing delirium after lung resection, with excess delirium concentrated in the emergence period.
AI-generated from the title and abstract; the full text is not read.
Key points
- Remimazolam failed to demonstrate noninferiority to propofol in preventing post-lung resection delirium.
- The increased incidence of delirium with remimazolam was primarily observed during the emergence period.
- The assessment frequency in the PACU (every 10 min) might be insufficient to precisely characterize brief, drug-related delirium fluctuations given median PACU stays of 61-66 min.
- Reported patient counts (1377-1440) correspond to a low average number of assessments per patient (6.1-6.3).
AI-generated from the title and abstract; the full text is not read.
Abstract
Remimazolam and emergence deliriumWang et al. report that remimazolam did not meet noninferiority to propofol for delirium after lung resection [1].We accept that conclusion and note the authors had already localised the excess to the emergence period.Our concern is narrower: the assessment-level results, which might distinguish sustained delirium from brief, drug-related fluctuation, cannot be interpreted as presented.Screening was performed every 10 min in the postanaesthesia care unit (PACU) and twice daily on postoperative days 1-3.Given the median PACU stays of 66 min and 61 min, this schedule could yield approximately 12 assessments per patient.The reported denominators of 1377 and 1440 correspond to only 6.1 and 6.3 assessments
The authors' abstract, as published at the source. Anaesthesia, 2026 · DOI ↗
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Field: Critical Care and Intensive Care Medicine
Critical Care and Intensive Care MedicineMedicine