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Biomedicines· 2026Q1· Review

Lichen-Derived Bioactive Compounds in Diabetes and Cardiovascular Risk: Experimental Evidence, Mechanisms, and Translational Challenges

Alfredo Torres-Benítez, Carlo Acierno, Davide Nilo, Roberta Cutellè et al.

Short summary

Lichen-derived compounds exhibit antioxidant, anti-inflammatory, and vasomodulatory effects in preclinical studies, but direct evidence for improving diabetes and cardiovascular risk markers in humans is lacking, with safety concerns like hepatotoxicity hindering clinical translation.

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Ecology, Evolution, Behavior and SystematicsAgricultural and Biological Sciences