Nanomaterials· 2026Q1
Improving the Hydrophilicity of the Drugs Paclitaxel, Violacein, and Tetrandrine Using Carbon-Based Quantum Dots
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- 2026year
Short summary
Carbon-based quantum dots (CQDs) significantly reduced the hydrophobicity of poorly soluble drugs Paclitaxel, Violacein, and Tetrandrine by lowering their partition coefficients (Log P) without encapsulation.
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Key points
- Carbon-based quantum dots (CQDs) were used to improve the solubility of Paclitaxel, Violacein, and Tetrandrine.
- Drug hydrophobicity was significantly reduced, evidenced by decreased partition coefficient (Log P) values.
- Paclitaxel's Log P dropped from 3.96 to 0.2.
- Violacein's Log P decreased from 3.34 to 1.17.
- Tetrandrine's Log P reduced from 2.5 to 1.57.
- The drugs were coupled with CQDs without encapsulation.
AI-generated from the title and abstract; the full text is not read.
Abstract
Carbon-based quantum dots and their nitrogen- and sulfur-doped derivatives were used as platforms to improve the aqueous solubility for Paclitaxel, Violacein and Tetrandrine, drugs with known high partition coefficients (Log P). Paclitaxel, Violacein and Tetrandrine showed a significant reduction in their partition coefficient values by coupling with the carbon-based quantum dots. Paclitaxel’s partition coefficient value decreased from 3.96 to 0.2, Violacein’s from 3.34 to 1.17, and Tetrandrine’s from 2.5 to 1.57, thus demonstrating a significant reduction in their hydrophobicity without being encapsulated. The efficiency of each type of carbon-based quantum dot in lowering each drug’s Log P varied and this behavior was correlated with the nature of the surface interaction between each drug and each of the carbon-based quantum dots.
The authors' abstract, as published at the source. Nanomaterials, 2026 · DOI ↗
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Field: Pharmacology (Medicine)
PharmacologyMedicine