Maternal-Fetal Medicine· 2026Q2
Sleep Duration and Metabolic Biomarkers During Pregnancy: A Longitudinal Study in a Multiracial Cohort
- 0citations
- Q2SCImago
- 2026year
Short summary
Pregnant women sleeping ≥ 9 hours had higher insulin and insulin resistance at 15-26 weeks, while those sleeping ≤ 6 hours had elevated glucose at 23-31 weeks.
AI-generated from the title and abstract; the full text is not read.
Key points
- Pregnant women sleeping ≥ 9 hours had significantly higher insulin (β=0.223) and insulin resistance (β=0.245) at 15-26 weeks gestation compared to those sleeping 7-8 hours.
- Pregnant women sleeping ≤ 6 hours had significantly elevated glucose concentrations (β=0.152) at 23-31 weeks gestation compared to those sleeping 7-8 hours.
- Metabolic biomarkers (glucose, insulin, C-peptide, hs-CRP) were measured longitudinally at 10-14, 15-26, and 23-31 weeks gestation.
- Habitual sleep duration was assessed via questionnaire as ≤ 6 hours, 7-8 hours, or ≥ 9 hours.
AI-generated from the title and abstract; the full text is not read.
Abstract
Abstract Objective: To examine associations between sleep duration and metabolic biomarkers in pregnant women. Methods: This nested case-control study involved 321 pregnant women from the Eunice Kennedy Shriver National Institute of Child Health and Human Development Fetal Growth Studies-Singleton Cohort in the United States. Plasma metabolic biomarkers (glucose, insulin, C-peptide, and high-sensitivity C-reactive protein) were measured in blood samples obtained on visit 0 (10–14 gestational weeks (GWs)), visit 1 (15–26 GWs), and visit 2 (23–31 GWs). The homeostasis model assessment of insulin resistance was calculated at visit 1, when fasting glucose and insulin measurements were available. At each visit, structured questionnaires were used to assess habitual sleep durations (≤ 6 hours, 7–8 hours (reference), or ≥ 9 hours) since the previous visit. Associations between sleep duration and log-transformed metabolic biomarkers adjusted for maternal age, gestational week, race/ethnicity, education level, family diabetes history, pre-pregnancy body mass index, and physical activity were estimated using weighted generalized estimating equation models. Results: During visit 1, women who slept for ≥ 9 hours had significantly higher insulin levels when compared with those who habitually slept for 7–8 hours since the previous visit (adjusted β = 0.223, 95% confidence interval ( CI ): 0.020–0.425) and homeostasis model assessment of insulin resistance (adjusted β = 0.245, 95% CI : 0.025–0.465). At visit 2, glucose concentrations were significantly elevated in women with an average sleep duration of ≤ 6 hours since the previous visit (adjusted β = 0.152, 95% CI : 0.028–0.276). Conclusion: Both insufficient and excessive sleep during pregnancy were associated with unfavorable profiles of metabolic biomarkers. Therefore, further investigation of the role of sleep health in maternal metabolic risk is warranted.
The authors' abstract, as published at the source. Maternal-Fetal Medicine, 2026 · DOI ↗
Continue with a free account
Ask the paper: 3 free questions a day about this paper; save it, get its citation, new summaries every day for your field. Takeaways are Premium.
Continue free on the webSign in with Google or Apple; no card needed. You come back to this paper.
On your phone:
Field: Experimental and Cognitive Psychology
Experimental and Cognitive PsychologyPsychology