Science· 2012Q1· Review
Photoacoustic Tomography: In Vivo Imaging from Organelles to Organs
- 4,278citations
- Q1SCImago
- 2012year
Short summary
Photoacoustic tomography (PAT) is an emerging imaging technology that uses light absorption to generate ultrasonic waves, enabling visualization of biological structures from organelles to organs in vivo.
AI-generated from the title and abstract; the full text is not read.
Key points
- PAT uses light absorption to generate detectable ultrasonic waves for imaging.
- It overcomes optical scattering in biological tissues.
- Resolution scales with depth, achieving up to 1/200th of the imaging depth (up to 7 cm).
- Provides anatomical, functional, metabolic, and molecular contrasts.
AI-generated from the title and abstract; the full text is not read.
Abstract
Photoacoustic tomography (PAT) can create multiscale multicontrast images of living biological structures ranging from organelles to organs. This emerging technology overcomes the high degree of scattering of optical photons in biological tissue by making use of the photoacoustic effect. Light absorption by molecules creates a thermally induced pressure jump that launches ultrasonic waves, which are received by acoustic detectors to form images. Different implementations of PAT allow the spatial resolution to be scaled with the desired imaging depth in tissue while a high depth-to-resolution ratio is maintained. As a rule of thumb, the achievable spatial resolution is on the order of 1/200 of the desired imaging depth, which can reach up to 7 centimeters. PAT provides anatomical, functional, metabolic, molecular, and genetic contrasts of vasculature, hemodynamics, oxygen metabolism, biomarkers, and gene expression. We review the state of the art of PAT for both biological and clinical studies and discuss future prospects.
The authors' abstract, as published at the source. Science, 2012 · DOI ↗
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Field: Biomedical Engineering
Biomedical EngineeringEngineering