Chemical Society Reviews· 2018Q1· Review
Photothermal therapy and photoacoustic imaging <i>via</i> nanotheranostics in fighting cancer
- 2,869citations
- Q1SCImago
- 2018year
Short summary
Nanotheranostics offer a combined approach for cancer treatment (photothermal therapy, PTT) and diagnosis (photoacoustic imaging, PAI) by converting light into heat or sound. This review highlights advancements in nanocarrier-based PTT and PAI for improved preclinical cancer outcomes.
AI-generated from the title and abstract; the full text is not read.
Key points
- Nanotheranostics integrate PTT (heat generation) and PAI (sound generation) for cancer treatment and diagnosis.
- Strategies to improve PTT include optimizing laser dosage, imaging guidance, and using nanocarriers with high photothermal conversion efficiency (PCE).
- Development of agents absorbing in the second NIR window and enhancing tumor accumulation are key for better PTT outcomes.
- Combining PTT with other therapies and exploring PAI's role in cancer research are emerging areas.
AI-generated from the title and abstract; the full text is not read.
Abstract
The nonradiative conversion of light energy into heat (photothermal therapy, PTT) or sound energy (photoacoustic imaging, PAI) has been intensively investigated for the treatment and diagnosis of cancer, respectively. By taking advantage of nanocarriers, both imaging and therapeutic functions together with enhanced tumour accumulation have been thoroughly studied to improve the pre-clinical efficiency of PAI and PTT. In this review, we first summarize the development of inorganic and organic nano photothermal transduction agents (PTAs) and strategies for improving the PTT outcomes, including applying appropriate laser dosage, guiding the treatment via imaging techniques, developing PTAs with absorption in the second NIR window, increasing photothermal conversion efficiency (PCE), and also increasing the accumulation of PTAs in tumours. Second, we introduce the advantages of combining PTT with other therapies in cancer treatment. Third, the emerging applications of PAI in cancer-related research are exemplified. Finally, the perspectives and challenges of PTT and PAI for combating cancer, especially regarding their clinical translation, are discussed. We believe that PTT and PAI having noteworthy features would become promising next-generation non-invasive cancer theranostic techniques and improve our ability to combat cancers.
The authors' abstract, as published at the source. Chemical Society Reviews, 2018 · DOI ↗
Continue with a free account
Ask the paper: 3 free questions a day about this paper; save it, get its citation, new summaries every day for your field. Takeaways are Premium.
Continue free on the webSign in with Google or Apple; no card needed. You come back to this paper.
On your phone:
Field: Biomedical Engineering
Biomedical EngineeringEngineering