Angewandte Chemie International Edition· 2018Q1· Review
Chemodynamic Therapy: Tumour Microenvironment‐Mediated Fenton and Fenton‐like Reactions
- 1,947citations
- Q1SCImago
- 2018year
Short summary
Nanotechnology can leverage tumour microenvironment acidity and excess hydrogen peroxide to generate hydroxyl radicals (.OH) via Fenton/Fenton-like reactions, enhancing cancer chemodynamic therapy (CDT).
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Key points
- Tumor microenvironments are acidic and overproduce hydrogen peroxide, ideal for Fenton/Fenton-like reactions.
- Nanotechnology can catalyze these reactions to generate hydroxyl radicals (.OH) for cancer therapy.
- Strategies to enhance .OH generation include nanomaterial choice, environmental modulation, and external energy.
- The review covers methods to overcome challenges and improve chemodynamic therapy (CDT) efficacy.
AI-generated from the title and abstract; the full text is not read.
Abstract
Abstract Tailored to the specific tumour microenvironment, which involves acidity and the overproduction of hydrogen peroxide, advanced nanotechnology has been introduced to generate the hydroxyl radical ( . OH) primarily for tumour chemodynamic therapy (CDT) through the Fenton and Fenton‐like reactions. Numerous studies have investigated the enhancement of CDT efficiency, primarily the increase in the amount of . OH generated. Notably, various strategies based on the Fenton reaction have been employed to enhance . OH generation, including nanomaterials selection, modulation of the reaction environment, and external energy fields stimulation, which are discussed systematically in this Minireview. Furthermore, the potential challenges and the methods used to facilitate CDT effectiveness are also presented to support this cutting‐edge research area.
The authors' abstract, as published at the source. Angewandte Chemie International Edition, 2018 · DOI ↗
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Field: Biomedical Engineering
Biomedical EngineeringEngineering