Foods· 2026Q1
Strain-Dependent Fermentation Enhances the Bioactivity of Gracilariopsis lemaneiformis Polysaccharide-Rich Fractions
- 0citations
- Q1SCImago
- 2026year
Short summary
Fermenting Gracilariopsis lemaneiformis (seaweed) with specific lactic acid bacteria strains significantly boosted the lifespan-extending and health-improving properties of its polysaccharide fractions, with L. plantarum HJ-S2 (GP-H) showing the most potent effects.
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Key points
- Fermentation with L. casei DS31 (GP-D) and L. plantarum HJ-S2 (GP-H) altered seaweed polysaccharide profiles.
- GP-D and GP-H fractions extended worm lifespan by 14.70% and 21.21%, respectively, versus 8.61% for unfermented GP.
- GP-H significantly improved worm heat/oxidative stress survival (+44%/+20%), locomotion, and redox homeostasis (SOD +19.5%, MDA -73.4%).
- Mechanistic studies implicated distinct stress-response pathways and complementary longevity networks.
AI-generated from the title and abstract; the full text is not read.
Abstract
Lactic acid bacterial fermentation offers a mild strategy for tailoring seaweed-derived carbohydrate fractions and strengthening their functional properties. In this study, polysaccharide-rich fractions were recovered from unfermented Gracilariopsis lemaneiformis (GP) and from biomass fermented with two marine-derived lactic acid bacteria, Lacticaseibacillus casei DS31 (GP-D) and Lactiplantibacillus plantarum HJ-S2 (GP-H). Fermentation changed the recovery of total and sulfated carbohydrates and altered monosaccharide profiles. In wild-type N2 worms, GP, GP-D, and GP-H extended mean lifespan by 8.61%, 14.70%, and 21.21%, respectively, and improved heat and oxidative stress survival (median survival +44% and +20% for GP-H, respectively), locomotion, redox homeostasis (SOD activity +19.5%, MDA content −73.4% for GP-H), and proteostasis-related phenotypes. Promoter–reporter assays, DAF-16::GFP localization, and transcriptomic profiling identified distinct treatment-associated stress-response programs. Lifespan extension also persisted in a daf-16 loss-of-function background, supporting contributions from complementary longevity networks. Collectively, strain-dependent fermentation reshaped G. lemaneiformis polysaccharide-rich fractions and enhanced their in vivo bioactivity, with GP-H producing the broadest improvement across the measured lifespan and healthspan endpoints.
The authors' abstract, as published at the source. Foods, 2026 · DOI ↗
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Field: Aquatic Science
Aquatic ScienceAgricultural and Biological Sciences