International Journal of Nanomedicine· 2017Q1· Review
The antimicrobial activity of nanoparticles: present situation and prospects for the future
- 3,983citations
- Q1SCImago
- 2017year
Short summary
Nanoparticles (NPs) offer a promising alternative to antibiotics for combating bacterial infections, with potential applications in coatings, drug delivery, diagnostics, and vaccines.
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Key points
- NPs are being developed as an alternative to antibiotics for treating bacterial infections.
- Applications include antibacterial coatings, drug delivery systems, bacterial detection, and vaccines.
- Key antibacterial mechanisms involve oxidative stress induction, metal ion release, and non-oxidative pathways.
- The multiple mechanisms of NP action make bacterial resistance development challenging.
AI-generated from the title and abstract; the full text is not read.
Abstract
Nanoparticles (NPs) are increasingly used to target bacteria as an alternative to antibiotics. Nanotechnology may be particularly advantageous in treating bacterial infections. Examples include the utilization of NPs in antibacterial coatings for implantable devices and medicinal materials to prevent infection and promote wound healing, in antibiotic delivery systems to treat disease, in bacterial detection systems to generate microbial diagnostics, and in antibacterial vaccines to control bacterial infections. The antibacterial mechanisms of NPs are poorly understood, but the currently accepted mechanisms include oxidative stress induction, metal ion release, and non-oxidative mechanisms. The multiple simultaneous mechanisms of action against microbes would require multiple simultaneous gene mutations in the same bacterial cell for antibacterial resistance to develop; therefore, it is difficult for bacterial cells to become resistant to NPs. In this review, we discuss the antibacterial mechanisms of NPs against bacteria and the factors that are involved. The limitations of current research are also discussed.
The authors' abstract, as published at the source. International Journal of Nanomedicine, 2017 · DOI ↗
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Field: Materials Chemistry
Materials ChemistryMaterials Science